|Group: Other Family: ULK Subfamily: Fused|
Description: serine/threonine kinase 36, fused homolog (Drosophila)
Gene Symbol: STK36
Synonyms: DKFZp434N0223, FU, KIAA1278
UniprotKB/SwissProt: STK36_HUMAN (Q9NRP7)
Function: Serine/threonine protein kinase required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur.
Subcellular Localization: Cytoplasm. Nucleus. Note=Low levels also present in the nucleus.