|Group: Other Family: WEE |
Description: protein kinase, membrane associated tyrosine/threonine 1
Gene Symbol: PKMYT1
Synonyms: DKFZp547K1610, FLJ20093, MYT1
UniprotKB/SwissProt: PMYT1_HUMAN (Q99640)
Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the cdc2 kinase specifically when cdc2 is complexed to cyclins. Mediates phosphorylation of cdc2 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of cdc2 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
Subcellular Localization: Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.