Regulatory Network in Protein Phosphorylation
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Kinase: MYT1 protein kinase, membrane associated tyrosine/threonine 1

Group: Other      Family: WEE      

Description: protein kinase, membrane associated tyrosine/threonine 1

Gene Symbol: PKMYT1

Synonyms: DKFZp547K1610, FLJ20093, MYT1

UniprotKB/SwissProt: PMYT1_HUMAN (Q99640)

Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the cdc2 kinase specifically when cdc2 is complexed to cyclins. Mediates phosphorylation of cdc2 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of cdc2 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

Subcellular Localization: Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.

Protein Domain:

The substrate proteins of kinase MYT1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CDC2CDC2_HUMANCell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23)(p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1). 3Show



The substrate proteins of kinase family WEE

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CDC2CDC2_HUMANCell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23)(p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1). 3Show
2CDK2CDK2_HUMANCell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase). 2Show