Regulatory Network in Protein Phosphorylation
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Kinase: Wee1 WEE1 homolog (S. pombe)

Group: Other      Family: WEE      

Description: WEE1 homolog (S. pombe)

Gene Symbol: WEE1

Synonyms: DKFZp686I18166, FLJ16446, WEE1hu

UniprotKB/SwissProt: WEE1_HUMAN (P30291)

Function: May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDC2 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDC2 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDC2 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDC2 does not occur.

Subcellular Localization: Nucleus.

Protein Domain:
PDB:1X8B

The substrate proteins of kinase Wee1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CDC2CDC2_HUMANCell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23)(p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1). 3Show
2CDK2CDK2_HUMANCell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase). 2Show



The substrate proteins of kinase family WEE

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CDC2CDC2_HUMANCell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23)(p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1). 3Show
2CDK2CDK2_HUMANCell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase). 2Show