|Group: Other Family: WEE |
Description: WEE1 homolog (S. pombe)
Gene Symbol: WEE1
Synonyms: DKFZp686I18166, FLJ16446, WEE1hu
UniprotKB/SwissProt: WEE1_HUMAN (P30291)
Function: May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDC2 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDC2 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDC2 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDC2 does not occur.
Subcellular Localization: Nucleus.