Regulatory Network in Protein Phosphorylation
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Kinase: Wnk1 WNK lysine deficient protein kinase 1

Group: Other      Family: WNK      

Description: WNK lysine deficient protein kinase 1

Gene Symbol: WNK1

Synonyms: KDP, KIAA0344, PHA2C, PRKWNK1

UniprotKB/SwissProt: WNK1_HUMAN (Q9H4A3)

Function: Controls sodium and chloride ion transport by inhibiting the activity of WNK4, potentially by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide- sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization.

Subcellular Localization: Cytoplasm.

Protein Domain:

The substrate proteins of kinase Wnk1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1OXSR1OXSR1_HUMANSerine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein). 2Show
2STK39STK39_HUMANSTE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1)(Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT). 2Show



The substrate proteins of kinase family WNK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1OXSR1OXSR1_HUMANSerine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein). 2Show
2STK39STK39_HUMANSTE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1)(Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT). 2Show