|Group: Other Family: WNK |
Description: WNK lysine deficient protein kinase 1
Gene Symbol: WNK1
Synonyms: KDP, KIAA0344, PHA2C, PRKWNK1
UniprotKB/SwissProt: WNK1_HUMAN (Q9H4A3)
Function: Controls sodium and chloride ion transport by inhibiting the activity of WNK4, potentially by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide- sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization.
Subcellular Localization: Cytoplasm.