Regulatory Network in Protein Phosphorylation
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Kinase: Wnk4 WNK lysine deficient protein kinase 4

Group: Other      Family: WNK      

Description: WNK lysine deficient protein kinase 4

Gene Symbol: WNK4

Synonyms: PHA2B, PRKWNK4

UniprotKB/SwissProt: WNK4_HUMAN (Q96J92)

Function: Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis (By similarity).

Subcellular Localization: Cell junction, tight junction (By similarity). Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction c

Protein Domain:

The substrate proteins of kinase family WNK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1OXSR1OXSR1_HUMANSerine/threonine-protein kinase OSR1 (EC (Oxidative stress-responsive 1 protein). 2Show
2STK39STK39_HUMANSTE20/SPS1-related proline-alanine-rich protein kinase (EC kinase) (Serine/threonine-protein kinase 39) (DCHT). 2Show