Regulatory Network in Protein Phosphorylation
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Kinase: COT mitogen-activated protein kinase kinase kinase 8

Group: STE      Family: STE-Unique      

Description: mitogen-activated protein kinase kinase kinase 8

Gene Symbol: MAP3K8

Synonyms: COT, EST, ESTF, FLJ10486, TPL2, Tpl-2, c-COT

UniprotKB/SwissProt: M3K8_HUMAN (P41279)

Function: Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.

Subcellular Localization: Cytoplasm.

Protein Domain:

The substrate proteins of kinase COT

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1MAP3K14M3K14_HUMANMitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK)(HsNIK). 1Show