|Group: STE Family: STE-Unique |
Description: mitogen-activated protein kinase kinase kinase 8
Gene Symbol: MAP3K8
Synonyms: COT, EST, ESTF, FLJ10486, TPL2, Tpl-2, c-COT
UniprotKB/SwissProt: M3K8_HUMAN (P41279)
Function: Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.
Subcellular Localization: Cytoplasm.