Regulatory Network in Protein Phosphorylation
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Kinase: NIK mitogen-activated protein kinase kinase kinase 14

Group: STE      Family: STE-Unique      

Description: mitogen-activated protein kinase kinase kinase 14

Gene Symbol: MAP3K14

Synonyms: FTDCR1B, HS, HSNIK, NIK

UniprotKB/SwissProt: M3K14_HUMAN (Q99558)

Function: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Induces the processing of NF-kappa-B 2/P100. Could act in a receptor-selective manner (By similarity).

Subcellular Localization: Cytoplasm.

Protein Domain:

The substrate proteins of kinase NIK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CHUKIKKA_HUMANInhibitor of nuclear factor kappa-B kinase subunit alpha(EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A)(IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinasealpha) (NFKBIKA). 3Show
2IKBKBIKKB_HUMANInhibitor of nuclear factor kappa-B kinase subunit beta (EC 2.7.11.10)(I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB). 2Show
3NFKB2NFKB2_HUMANNuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2)(H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10)(Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit]. 6Show