Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinome Table]
Kinase: MAP3K5 mitogen-activated protein kinase kinase kinase 5

Group: STE      Family: STE11      Subfamily: ASK

Description: mitogen-activated protein kinase kinase kinase 5

Gene Symbol: MAP3K5

Synonyms: ASK1, MAPKKK5, MEKK5

UniprotKB/SwissProt: M3K5_HUMAN (Q99683)

Function: Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.

Subcellular Localization:

Protein Domain:
PDB:2CLQ

The substrate proteins of kinase MAP3K5

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1MAP3K5M3K5_HUMANMitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25)(MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1). 2Show
2MAP2K4MP2K4_HUMANDual specificity mitogen-activated protein kinase kinase 4(EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-JunN-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1). 1Show
3TNNT2TNNT2_HUMANTroponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT). 2Show



The substrate proteins of kinase family ASK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1PASKPASK_HUMANPAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1)(PAS-kinase) (PASKIN) (hPASK). 4Show