|Group: STE Family: STE11 Subfamily: ASK|
Description: mitogen-activated protein kinase kinase kinase 5
Gene Symbol: MAP3K5
Synonyms: ASK1, MAPKKK5, MEKK5
UniprotKB/SwissProt: M3K5_HUMAN (Q99683)
Function: Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.