|Group: STE Family: STE11 Subfamily: MEKK2|
Description: mitogen-activated protein kinase kinase kinase 2
Gene Symbol: MAP3K2
Synonyms: MEKK2, MEKK2B
UniprotKB/SwissProt: M3K2_HUMAN (Q9Y2U5)
Function: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.
Subcellular Localization: Cytoplasm. Note=Upon EGF stimulation, translocates into the nucleus.