Regulatory Network in Protein Phosphorylation
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Kinase: MAP3K2 mitogen-activated protein kinase kinase kinase 2

Group: STE      Family: STE11      Subfamily: MEKK2

Description: mitogen-activated protein kinase kinase kinase 2

Gene Symbol: MAP3K2

Synonyms: MEKK2, MEKK2B

UniprotKB/SwissProt: M3K2_HUMAN (Q9Y2U5)

Function: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.

Subcellular Localization: Cytoplasm. Note=Upon EGF stimulation, translocates into the nucleus.

Protein Domain:
PDB:2CU1