|Group: STE Family: STE11 Subfamily: MEKK15|
Description: yeast Sps1/Ste20-related kinase 4 (S. cerevisiae)
Gene Symbol: YSK4
Synonyms: FLJ23074, RCK
UniprotKB/SwissProt: M3K8_HUMAN (P41279)
Function: Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.
Subcellular Localization: Cytoplasm.