Regulatory Network in Protein Phosphorylation
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Kinase: MAP3K8 yeast Sps1/Ste20-related kinase 4 (S. cerevisiae)

Group: STE      Family: STE11      Subfamily: MEKK15

Description: yeast Sps1/Ste20-related kinase 4 (S. cerevisiae)

Gene Symbol: YSK4

Synonyms: FLJ23074, RCK

UniprotKB/SwissProt: M3K8_HUMAN (P41279)

Function: Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.

Subcellular Localization: Cytoplasm.

Protein Domain:

The substrate proteins of kinase MAP3K8

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1MAP3K14M3K14_HUMANMitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK)(HsNIK). 2Show
2MAP2K1MP2K1_HUMANDual specificity mitogen-activated protein kinase kinase 1(EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)(MAPK/ERK kinase 1) (MEK1). 2Show
3MAP2K2MP2K2_HUMANDual specificity mitogen-activated protein kinase kinase 2(EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2)(MAPK/ERK kinase 2) (MEK2). 2Show