Regulatory Network in Protein Phosphorylation
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Kinase: MAP3K1 mitogen-activated protein kinase kinase kinase 1

Group: STE      Family: STE11      Subfamily: MEKK1

Description: mitogen-activated protein kinase kinase kinase 1

Gene Symbol: MAP3K1

Synonyms: MAPKKK1, MEKK, MEKK1

UniprotKB/SwissProt: M3K1_HUMAN (Q13233)

Function: Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase MAP3K1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CHUKIKKA_HUMANInhibitor of nuclear factor kappa-B kinase subunit alpha(EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A)(IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinasealpha) (NFKBIKA). 1Show
2MAP3K11M3K11_HUMANMitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25)(Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase). 2Show
3MAP2K4MP2K4_HUMANDual specificity mitogen-activated protein kinase kinase 4(EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-JunN-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1). 1Show
4MAP2K7MP2K7_HUMANDual specificity mitogen-activated protein kinase kinase 7(EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7)(JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNKkinase 2) (JNKK 2). 2Show
5NFKB2NFKB2_HUMANNuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2)(H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10)(Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit]. 4Show