Regulatory Network in Protein Phosphorylation
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Kinase: GCK mitogen-activated protein kinase kinase kinase kinase 2

Group: STE      Family: STE20      Subfamily: KHS

Description: mitogen-activated protein kinase kinase kinase kinase 2

Gene Symbol: MAP4K2

Synonyms: BL44, GCK, RAB8IP

UniprotKB/SwissProt: M4K2_HUMAN (Q12851)

Function: Enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. May play a role in the regulation of vesicle targeting or fusion.

Subcellular Localization: Cytoplasm (By similarity). Basolateral cell membrane; Peripheral membrane protein (By similarity). Golgi apparatus membrane; Peripheral membrane protein (By similarity).

Protein Domain:

The substrate proteins of kinase GCK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1PRH1PRPC_HUMANSalivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP-2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotidacidic protein) (Pa) (Parotid isoelectric focusing variant protein)(PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivaryacidic proline-rich phosphoprotein 1/2; Salivary acidic proline-richphosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); PeptideP-C]. 1Show