Regulatory Network in Protein Phosphorylation
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Kinase: HPK1 mitogen-activated protein kinase kinase kinase kinase 1

Group: STE      Family: STE20      Subfamily: KHS

Description: mitogen-activated protein kinase kinase kinase kinase 1

Gene Symbol: MAP4K1

Synonyms: HPK1

UniprotKB/SwissProt: M4K1_HUMAN (Q92918)

Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase HPK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1LCP2LCP2_HUMANLymphocyte cytosolic protein 2 (SH2 domain-containing leukocyteprotein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76). 1Show
2MAP3K10M3K10_HUMANMitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25)(Mixed lineage kinase 2) (Protein kinase MST). 1Show
3MAP3K11M3K11_HUMANMitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25)(Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase). 3Show
4MLK4M3KL4_HUMANMitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixedlineage kinase 4). 1Show