Regulatory Network in Protein Phosphorylation
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Kinase: MST1 serine/threonine kinase 4

Group: STE      Family: STE20      Subfamily: MST

Description: serine/threonine kinase 4

Gene Symbol: STK4

Synonyms: DKFZp686A2068, KRS2, MST1, YSK3

UniprotKB/SwissProt: STK4_HUMAN (Q13043)

Function: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Phosphorylates 'Ser-14' of histone H2B during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.

Subcellular Localization: Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.

Protein Domain:
PDB:2JO8

The substrate proteins of kinase MST1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1FOXO3FOXO3_HUMANForkhead box protein O3 (Forkhead in rhabdomyosarcoma-like 1) (AF6q21protein). 1Show
2HIST1H2BBH2B1B_HUMANHistone H2B type 1-B (H2B.f) (H2B/f) (H2B.1). 2Show
3HIST1H2BCH2B1C_HUMANHistone H2B type 1-C/E/F/G/I (H2B.a/g/h/k/l) (H2B.1 A) (H2B/a) (H2B/g)(H2B/h) (H2B/k) (H2B/l). 1Show
4HIST1H2BDH2B1D_HUMANHistone H2B type 1-D (H2B.b) (H2B/b) (H2B.1 B) (HIRA-interactingprotein 2). 1Show
5HIST1H2BHH2B1H_HUMANHistone H2B type 1-H (H2B.j) (H2B/j). 1Show
6HIST1H2BJH2B1J_HUMANHistone H2B type 1-J (H2B.r) (H2B/r) (H2B.1). 1Show
7HIST1H2BKH2B1K_HUMANHistone H2B type 1-K (H2B K) (HIRA-interacting protein 1). 1Show
8HIST1H2BLH2B1L_HUMANHistone H2B type 1-L (H2B.c) (H2B/c). 1Show
9HIST1H2BMH2B1M_HUMANHistone H2B type 1-M (H2B.e) (H2B/e). 1Show
10HIST1H2BNH2B1N_HUMANHistone H2B type 1-N (H2B.d) (H2B/d). 1Show
11HIST1H2BOH2B1O_HUMANHistone H2B type 1-O (H2B.n) (H2B/n) (H2B.2). 1Show
12HIST2H2BCH2B2C_HUMANHistone H2B type 2-C (H2.t) (H2B/t). 1Show
13HIST2H2BDH2B2D_HUMANHistone H2B type 2-D. 1Show
14HIST2H2BEH2B2E_HUMANHistone H2B type 2-E (H2B.q) (H2B/q) (H2B-GL105). 1Show
15HIST2H2BFH2B2F_HUMANHistone H2B type 2-F. 1Show
16HIST3H2BBH2B3B_HUMANHistone H2B type 3-B (H2B type 12). 1Show
17H2BFSH2BFS_HUMANHistone H2B type F-S (H2B.s) (H2B/s). 1Show
18STK4STK4_HUMANSerine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinaseMST1) (MST-1) (Mammalian STE20-like protein kinase 1)(Serine/threonine-protein kinase Krs-2). 5Show



The substrate proteins of kinase family MST

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1FOXO3FOXO3_HUMANForkhead box protein O3 (Forkhead in rhabdomyosarcoma-like 1) (AF6q21protein). 1Show
2HIST1H2BBH2B1B_HUMANHistone H2B type 1-B (H2B.f) (H2B/f) (H2B.1). 2Show
3HIST1H2BCH2B1C_HUMANHistone H2B type 1-C/E/F/G/I (H2B.a/g/h/k/l) (H2B.1 A) (H2B/a) (H2B/g)(H2B/h) (H2B/k) (H2B/l). 1Show
4HIST1H2BDH2B1D_HUMANHistone H2B type 1-D (H2B.b) (H2B/b) (H2B.1 B) (HIRA-interactingprotein 2). 1Show
5HIST1H2BHH2B1H_HUMANHistone H2B type 1-H (H2B.j) (H2B/j). 1Show
6HIST1H2BJH2B1J_HUMANHistone H2B type 1-J (H2B.r) (H2B/r) (H2B.1). 1Show
7HIST1H2BKH2B1K_HUMANHistone H2B type 1-K (H2B K) (HIRA-interacting protein 1). 1Show
8HIST1H2BLH2B1L_HUMANHistone H2B type 1-L (H2B.c) (H2B/c). 1Show
9HIST1H2BMH2B1M_HUMANHistone H2B type 1-M (H2B.e) (H2B/e). 1Show
10HIST1H2BNH2B1N_HUMANHistone H2B type 1-N (H2B.d) (H2B/d). 1Show
11HIST1H2BOH2B1O_HUMANHistone H2B type 1-O (H2B.n) (H2B/n) (H2B.2). 1Show
12HIST2H2BCH2B2C_HUMANHistone H2B type 2-C (H2.t) (H2B/t). 1Show
13HIST2H2BDH2B2D_HUMANHistone H2B type 2-D. 1Show
14HIST2H2BEH2B2E_HUMANHistone H2B type 2-E (H2B.q) (H2B/q) (H2B-GL105). 1Show
15HIST2H2BFH2B2F_HUMANHistone H2B type 2-F. 1Show
16HIST3H2BBH2B3B_HUMANHistone H2B type 3-B (H2B type 12). 1Show
17H2BFSH2BFS_HUMANHistone H2B type F-S (H2B.s) (H2B/s). 1Show
18LATS1LATS1_HUMANSerine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumorsuppressor homolog 1) (WARTS protein kinase) (h-warts). 2Show
19STK38LST38L_HUMANSerine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 proteinkinase) (Nuclear Dbf2-related kinase 2). 1Show
20STK3STK3_HUMANSerine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinaseMST2) (MST-2) (Mammalian STE20-like protein kinase 2)(Serine/threonine-protein kinase Krs-1). 1Show
21STK4STK4_HUMANSerine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinaseMST1) (MST-1) (Mammalian STE20-like protein kinase 1)(Serine/threonine-protein kinase Krs-2). 5Show