|Group: STE Family: STE20 Subfamily: MST|
Description: serine/threonine kinase 4
Gene Symbol: STK4
Synonyms: DKFZp686A2068, KRS2, MST1, YSK3
UniprotKB/SwissProt: STK4_HUMAN (Q13043)
Function: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Phosphorylates 'Ser-14' of histone H2B during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
Subcellular Localization: Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.