Regulatory Network in Protein Phosphorylation
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Kinase: PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)

Group: STE      Family: STE20      Subfamily: PAKA

Description: p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)

Gene Symbol: PAK1

Synonyms: MGC130000, MGC130001, PAKalpha

UniprotKB/SwissProt: PAK1_HUMAN (Q13153)

Function: The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Subcellular Localization: Cytoplasm. Cell junction, focal adhesion. Note=Recruited to focal adhesions upon activation.

Protein Domain:
PDB:1F3M

The substrate proteins of kinase PAK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ARPC1BARC1B_HUMANActin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDasubunit) (p41-ARC). 1Show
2ARHGEF2ARHG2_HUMANRho/Rac guanine nucleotide exchange factor 2 (Protein GEF-H1)(Proliferating cell nucleolar antigen p40). 2Show
3BRAFBRAF1_HUMANB-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1)(p94) (v-Raf murine sarcoma viral oncogene homolog B1). 1Show
4ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 2Show
5FLNAFLNA_HUMANFilamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-bindingprotein) (Actin-binding protein 280) (ABP-280) (Non-muscle filamin). 1Show
6FOXL2FOXL2_HUMANForkhead box protein L2. 2Show
7FOXO1FOXO1_HUMANForkhead box protein O1 (Forkhead box protein O1A) (Forkhead inrhabdomyosarcoma). 1Show
8ARHGDIAGDIR1_HUMANRho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha). 2Show
9GNAZGNAZ_HUMANGuanine nucleotide-binding protein G(z) subunit alpha (G(x) alphachain) (Gz-alpha). 1Show
10LIMK1LIMK1_HUMANLIM domain kinase 1 (EC 2.7.11.1) (LIMK-1). 2Show
11NF2MERL_HUMANMerlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2)(Schwannomin) (Schwannomerlin). 1Show
12MAP2K1MP2K1_HUMANDual specificity mitogen-activated protein kinase kinase 1(EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)(MAPK/ERK kinase 1) (MEK1). 2Show
13MYLKMYLK_HUMANMyosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK)(Telokin) (Kinase-related protein) (KRP). 1Show
14PAK1PAK1_HUMANSerine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activatedkinase 1) (PAK-1) (p65-PAK) (Alpha-PAK). 8Show
15PGAM1PGAM1_HUMANPhosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13)(Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1). 2Show
16PGM1PGM1_HUMANPhosphoglucomutase-1 (EC 5.4.2.2) (Glucose phosphomutase 1) (PGM 1). 1Show
17GNAZQ8IY73_HUMANGuanine nucleotide binding protein (G protein), alpha z polypeptide. 1Show
18ARHGEF2Q8TDA3_HUMANGuanine nucleotide exchange factor GEF-H1 (Rho/rac guanine nucleotideexchange factor (GEF) 2, isoform CRA_c) (Rho/rac guanine nucleotideexchange factor (GEF) 2). 1Show
19RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf). 3Show
20SNAI1SNAI_HUMANZinc finger protein SNAI1 (Protein snail homolog) (Protein sna). 1Show
21STMN1STMN1_HUMANStathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18)(Leukemia-associated phosphoprotein p18) (pp17) (Prosolin)(Metablastin) (Protein Pr22). 1Show
22SYN1SYN1_HUMANSynapsin-1 (Synapsin I) (Brain protein 4.1). 1Show
23TBCBTBCB_HUMANTubulin folding cofactor B (Tubulin-specific chaperone B)(Cytoskeleton-associated protein 1) (Cytoskeleton-associated proteinCKAPI). 2Show
24VIMVIME_HUMANVimentin. 3Show