Regulatory Network in Protein Phosphorylation
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Kinase: PAK2 p21 (CDKN1A)-activated kinase 2

Group: STE      Family: STE20      Subfamily: PAKA

Description: p21 (CDKN1A)-activated kinase 2

Gene Symbol: PAK2

Synonyms: PAK65, PAKgamma

UniprotKB/SwissProt: PAK2_HUMAN (Q13177)

Function: The activated kinase acts on a variety of targets. Phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase- activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form.

Subcellular Localization: Serine/threonine-protein kinase PAK 2: Cytoplasm. PAK-2p34: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p

Protein Domain:

The substrate proteins of kinase PAK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1NF2MERL_HUMANMerlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2)(Schwannomin) (Schwannomerlin). 1Show
2MKNK1MKNK1_HUMANMAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1)(MAP kinase signal-integrating kinase 1) (Mnk1). 2Show
3MYL9MLRN_HUMANMyosin regulatory light chain 2, smooth muscle isoform (Myosin RLC)(Myosin regulatory light chain 9) (LC20). 1Show
4MYLKMYLK_HUMANMyosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK)(Telokin) (Kinase-related protein) (KRP). 2Show
5PAK2PAK2_HUMANSerine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activatedkinase 2) (PAK-2) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p58) [Contains:PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]. 7Show
6PRLPRL_HUMANProlactin precursor (PRL). 1Show
7RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf). 1Show
8RPS6RS6_HUMAN40S ribosomal protein S6 (Phosphoprotein NP33). 4Show
9SYN1SYN1_HUMANSynapsin-1 (Synapsin I) (Brain protein 4.1). 2Show
10VIMVIME_HUMANVimentin. 5Show