Regulatory Network in Protein Phosphorylation
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Kinase: MAP2K2 mitogen-activated protein kinase kinase 2

Group: STE      Family: STE7      Subfamily: MEK1

Description: mitogen-activated protein kinase kinase 2

Gene Symbol: MAP2K2

Synonyms: MAPKK2, MEK2, MKK2, PRKMK2

UniprotKB/SwissProt: MP2K2_HUMAN (P36507)

Function: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).

Subcellular Localization:

Protein Domain:
PDB:1S9I

The substrate proteins of kinase MAP2K2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CASP9CASP9_HUMANCaspase-9 precursor (EC 3.4.22.62) (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10]. 1Show
2MAPK3MK03_HUMANMitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase)(MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase). 4Show