Regulatory Network in Protein Phosphorylation
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Kinase: MAP2K3 mitogen-activated protein kinase kinase 3

Group: STE      Family: STE7      Subfamily: MEK3

Description: mitogen-activated protein kinase kinase 3

Gene Symbol: MAP2K3

Synonyms: MAPKK3, MEK3, MKK3, PRKMK3

UniprotKB/SwissProt: MP2K3_HUMAN (P46734)

Function: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase MAP2K3

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1MAPK12MK12_HUMANMitogen-activated protein kinase 12 (EC (Extracellularsignal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated proteinkinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38gamma). 3Show
2MAPK14MK14_HUMANMitogen-activated protein kinase 14 (EC (Mitogen-activatedprotein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressiveanti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP)(MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A). 3Show
3MAP2K3MP2K3_HUMANDual specificity mitogen-activated protein kinase kinase 3(EC (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3). 2Show