Regulatory Network in Protein Phosphorylation
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Kinase: MAP2K4 mitogen-activated protein kinase kinase 4

Group: STE      Family: STE7      Subfamily: MEK4

Description: mitogen-activated protein kinase kinase 4

Gene Symbol: MAP2K4

Synonyms: JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SEK1, SERK1

UniprotKB/SwissProt: MP2K4_HUMAN (P45985)

Function: Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase MAP2K4

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1MAPK8MK08_HUMANMitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activatedprotein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46). 2Show
2MAPK9MK09_HUMANMitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activatedprotein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55). 2Show
3MAPK10MK10_HUMANMitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activatedprotein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p493F12). 3Show
4MAPK12MK12_HUMANMitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated proteinkinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38gamma). 2Show
5MAP2K4MP2K4_HUMANDual specificity mitogen-activated protein kinase kinase 4(EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-JunN-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1). 4Show
6RXRARXRA_HUMANRetinoic acid receptor RXR-alpha (Retinoid X receptor alpha) (Nuclearreceptor subfamily 2 group B member 1). 1Show