Regulatory Network in Protein Phosphorylation
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Kinase: MAP2K1 mitogen-activated protein kinase kinase 1

Group: STE      Family: STE7      Subfamily: MEK1

Description: mitogen-activated protein kinase kinase 1

Gene Symbol: MAP2K1

Synonyms: MAPKK1, MEK1, MKK1, PRKMK1

UniprotKB/SwissProt: MP2K1_HUMAN (Q02750)

Function: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

Subcellular Localization:

Protein Domain:
PDB:1S9J

The substrate proteins of kinase MAP2K1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CASP9CASP9_HUMANCaspase-9 precursor (EC 3.4.22.62) (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10]. 1Show
2GSK3BGSK3B_HUMANGlycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta). 1Show
3RPS6KA4KS6A4_HUMANRibosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6kinase 4) (Ribosomal protein kinase B) (RSKB). 5Show
4MAPK1MK01_HUMANMitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1). 3Show
5MAPK3MK03_HUMANMitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase)(MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase). 2Show
6MAP2K1MP2K1_HUMANDual specificity mitogen-activated protein kinase kinase 1(EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)(MAPK/ERK kinase 1) (MEK1). 1Show