Regulatory Network in Protein Phosphorylation
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Kinase: MAP2K6 mitogen-activated protein kinase kinase 6

Group: STE      Family: STE7      Subfamily: MEK3

Description: mitogen-activated protein kinase kinase 6

Gene Symbol: MAP2K6

Synonyms: MAPKK6, MEK6, MKK6, PRKMK6, SAPKK3

UniprotKB/SwissProt: MP2K6_HUMAN (P52564)

Function: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase MAP2K6

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1MAPK12MK12_HUMANMitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated proteinkinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38gamma). 3Show
2MAPK13MK13_HUMANMitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activatedprotein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAPkinase p38 delta). 1Show
3MAPK14MK14_HUMANMitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activatedprotein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressiveanti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP)(MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A). 4Show
4PAK6PAK6_HUMANSerine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activatedkinase 6) (PAK-6) (PAK-5). 2Show
5STAT4STAT4_HUMANSignal transducer and activator of transcription 4. 1Show