Regulatory Network in Protein Phosphorylation
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Kinase: MAP2K5 mitogen-activated protein kinase kinase 5

Group: STE      Family: STE7      Subfamily: MEK5

Description: mitogen-activated protein kinase kinase 5

Gene Symbol: MAP2K5

Synonyms: HsT17454, MAPKK5, MEK5, PRKMK5

UniprotKB/SwissProt: MP2K5_HUMAN (Q13163)

Function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.

Subcellular Localization:

Protein Domain:
PDB:2NPT