Regulatory Network in Protein Phosphorylation
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Kinase: ALK anaplastic lymphoma kinase (Ki-1)

Group: TK      Family: ALK      

Description: anaplastic lymphoma kinase (Ki-1)

Gene Symbol: ALK

Synonyms: CD246, TFG/ALK

UniprotKB/SwissProt: ALK_HUMAN (Q9UM73)

Function: Orphan receptor with a tyrosine-protein kinase activity. Appears to play an important role in the normal development and function of the nervous system. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:

The substrate proteins of kinase ALK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ALKALK_HUMANALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplasticlymphoma kinase) (CD246 antigen). 6Show
2ZC3HC1NIPA_HUMANNuclear-interacting partner of ALK (Nuclear-interacting partner ofanaplastic lymphoma kinase) (hNIPA) (Zinc finger C3HC-type protein 1). 2Show
3SMAD1SMAD1_HUMANMothers against decapentaplegic homolog 1 (SMAD 1) (Mothers againstDPP homolog 1) (Mad-related protein 1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) (hSMAD1) (JV4-1). 3Show
4SMAD2SMAD2_HUMANMothers against decapentaplegic homolog 2 (SMAD 2) (Mothers againstDPP homolog 2) (Mad-related protein 2) (hMAD-2) (JV18-1) (hSMAD2). 3Show
5STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 1Show



The substrate proteins of kinase family ALK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ALKALK_HUMANALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplasticlymphoma kinase) (CD246 antigen). 6Show
2ZC3HC1NIPA_HUMANNuclear-interacting partner of ALK (Nuclear-interacting partner ofanaplastic lymphoma kinase) (hNIPA) (Zinc finger C3HC-type protein 1). 2Show
3SMAD1SMAD1_HUMANMothers against decapentaplegic homolog 1 (SMAD 1) (Mothers againstDPP homolog 1) (Mad-related protein 1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) (hSMAD1) (JV4-1). 3Show
4SMAD2SMAD2_HUMANMothers against decapentaplegic homolog 2 (SMAD 2) (Mothers againstDPP homolog 2) (Mad-related protein 2) (hMAD-2) (JV18-1) (hSMAD2). 3Show
5STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 1Show