Regulatory Network in Protein Phosphorylation
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Kinase: ABL1(Abl) v-abl Abelson murine leukemia viral oncogene homolog 1

Group: TK      Family: Abl      

Description: v-abl Abelson murine leukemia viral oncogene homolog 1

Gene Symbol: ABL1

Synonyms: ABL, JTK7, c-ABL, p150, v-abl

UniprotKB/SwissProt: ABL1_HUMAN (P00519)

Function: Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.

Subcellular Localization: Cytoplasm. Nucleus. Note=The myristoylated c-ABL protein is reported to be nuclear.

Protein Domain:
PDB:1AB2

The substrate proteins of kinase ABL1(Abl)

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ABL1ABL1_HUMANProto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1). 3Show
2ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 1Show
3BCRBCR_HUMANBreakpoint cluster region protein (EC 2.7.11.1) (Renal carcinomaantigen NY-REN-26). 2Show
4BTKBTK_HUMANTyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK). 2Show
5CASP9CASP9_HUMANCaspase-9 precursor (EC 3.4.22.62) (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10]. 2Show
6CATCATA_HUMANCatalase (EC 1.11.1.6). 4Show
7CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 2Show
8CD19CD19_HUMANB-lymphocyte antigen CD19 precursor (Differentiation antigen CD19) (B-lymphocyte surface antigen B4) (Leu-12). 1Show
9CDK5CDK5_HUMANCell division protein kinase 5 (EC 2.7.11.22) (Cyclin-dependent kinase5) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)(Serine/threonine-protein kinase PSSALRE). 3Show
10CDKN1BCDN1B_HUMANCyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1). 1Show
11CRKLCRKL_HUMANCrk-like protein. 1Show
12CRKCRK_HUMANProto-oncogene C-crk (p38) (Adapter molecule crk). 3Show
13DCXDCX_HUMANNeuronal migration protein doublecortin (Lissencephalin-X) (Lis-X)(Doublin). 1Show
14GPX1GPX1_HUMANGlutathione peroxidase 1 (EC 1.11.1.9) (GSHPx-1) (GPx-1) (Cellularglutathione peroxidase). 3Show
15NFKBIAIKBA_HUMANNF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer-binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IkB-alpha). 1Show
16JAK2JAK2_HUMANTyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2). 1Show
17JUNJUN_HUMANTranscription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogenec-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). 1Show
18PRKD1KPCD1_HUMANSerine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Proteinkinase D) (Protein kinase C mu type) (nPKC-mu). 5Show
19MAP4K1M4K1_HUMANMitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1)(MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)(Hematopoietic progenitor kinase). 1Show
20MDM2MDM2_HUMANE3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-) (p53-binding proteinMdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2). 2Show
21MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 1Show
22TP73P73_HUMANTumor protein p73 (p53-like transcription factor) (p53-relatedprotein). 3Show
23PLSCR1PLS1_HUMANPhospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependentphospholipid scramblase 1) (Erythrocyte phospholipid scramblase)(MmTRA1b). 6Show
24PLSCR4PLS4_HUMANPhospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependentphospholipid scramblase 4) (TRA1) (Cell growth-inhibiting gene 43protein). 4Show
25PSTPIP1PPIP1_HUMANProline-serine-threonine phosphatase-interacting protein 1 (PESTphosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP). 2Show
26PTPN6PTN6_HUMANTyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cellprotein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphataseSHP-1). 2Show
27RAD51RAD51_HUMANDNA repair protein RAD51 homolog 1 (hRAD51) (HsRAD51). 4Show
28RAD52RAD52_HUMANDNA repair protein RAD52 homolog. 2Show
29RAD9ARAD9A_HUMANCell cycle checkpoint control protein RAD9A (EC 3.1.11.2) (DNA repairexonuclease rad9 homolog A) (hRAD9). 2Show
30ROBO1ROBO1_HUMANRoundabout homolog 1 precursor (H-Robo-1) (Deleted in U twentytwenty). 3Show
31SIVA1SIVA_HUMANApoptosis regulatory protein Siva (CD27-binding protein) (CD27BP). 2Show
32MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 1Show
33TOP1TOP1_HUMANDNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I). 1Show
34WASF2WASF2_HUMANWiskott-Aldrich syndrome protein family member 2 (WASP family proteinmember 2) (Protein WAVE-2) (Verprolin homology domain-containingprotein 2). 1Show
35WASLWASL_HUMANNeural Wiskott-Aldrich syndrome protein (N-WASP). 2Show



The substrate proteins of kinase family Abl

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ABL1ABL1_HUMANProto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1). 3Show
2ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 1Show
3BCRBCR_HUMANBreakpoint cluster region protein (EC 2.7.11.1) (Renal carcinomaantigen NY-REN-26). 2Show
4BTKBTK_HUMANTyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK). 2Show
5CASP9CASP9_HUMANCaspase-9 precursor (EC 3.4.22.62) (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10]. 2Show
6CATCATA_HUMANCatalase (EC 1.11.1.6). 4Show
7CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 2Show
8CD19CD19_HUMANB-lymphocyte antigen CD19 precursor (Differentiation antigen CD19) (B-lymphocyte surface antigen B4) (Leu-12). 1Show
9CDK5CDK5_HUMANCell division protein kinase 5 (EC 2.7.11.22) (Cyclin-dependent kinase5) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)(Serine/threonine-protein kinase PSSALRE). 3Show
10CDKN1BCDN1B_HUMANCyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1). 1Show
11CRKLCRKL_HUMANCrk-like protein. 1Show
12CRKCRK_HUMANProto-oncogene C-crk (p38) (Adapter molecule crk). 3Show
13DCXDCX_HUMANNeuronal migration protein doublecortin (Lissencephalin-X) (Lis-X)(Doublin). 1Show
14GPX1GPX1_HUMANGlutathione peroxidase 1 (EC 1.11.1.9) (GSHPx-1) (GPx-1) (Cellularglutathione peroxidase). 3Show
15NFKBIAIKBA_HUMANNF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer-binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IkB-alpha). 1Show
16JAK2JAK2_HUMANTyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2). 1Show
17JUNJUN_HUMANTranscription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogenec-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). 1Show
18PRKD1KPCD1_HUMANSerine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Proteinkinase D) (Protein kinase C mu type) (nPKC-mu). 5Show
19MAP4K1M4K1_HUMANMitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1)(MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)(Hematopoietic progenitor kinase). 1Show
20MDM2MDM2_HUMANE3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-) (p53-binding proteinMdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2). 2Show
21MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 1Show
22TP73P73_HUMANTumor protein p73 (p53-like transcription factor) (p53-relatedprotein). 3Show
23PLSCR1PLS1_HUMANPhospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependentphospholipid scramblase 1) (Erythrocyte phospholipid scramblase)(MmTRA1b). 6Show
24PLSCR4PLS4_HUMANPhospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependentphospholipid scramblase 4) (TRA1) (Cell growth-inhibiting gene 43protein). 4Show
25PSTPIP1PPIP1_HUMANProline-serine-threonine phosphatase-interacting protein 1 (PESTphosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP). 2Show
26PTPN6PTN6_HUMANTyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cellprotein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphataseSHP-1). 2Show
27RAD51RAD51_HUMANDNA repair protein RAD51 homolog 1 (hRAD51) (HsRAD51). 4Show
28RAD52RAD52_HUMANDNA repair protein RAD52 homolog. 2Show
29RAD9ARAD9A_HUMANCell cycle checkpoint control protein RAD9A (EC 3.1.11.2) (DNA repairexonuclease rad9 homolog A) (hRAD9). 2Show
30ROBO1ROBO1_HUMANRoundabout homolog 1 precursor (H-Robo-1) (Deleted in U twentytwenty). 3Show
31SIVA1SIVA_HUMANApoptosis regulatory protein Siva (CD27-binding protein) (CD27BP). 2Show
32MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 1Show
33TOP1TOP1_HUMANDNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I). 1Show
34WASF2WASF2_HUMANWiskott-Aldrich syndrome protein family member 2 (WASP family proteinmember 2) (Protein WAVE-2) (Verprolin homology domain-containingprotein 2). 1Show
35WASLWASL_HUMANNeural Wiskott-Aldrich syndrome protein (N-WASP). 2Show