Regulatory Network in Protein Phosphorylation
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Kinase: ABL1(Abl) v-abl Abelson murine leukemia viral oncogene homolog 1

Group: TK      Family: Abl      

Description: v-abl Abelson murine leukemia viral oncogene homolog 1

Gene Symbol: ABL1

Synonyms: ABL, JTK7, c-ABL, p150, v-abl

UniprotKB/SwissProt: ABL1_HUMAN (P00519)

Function: Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.

Subcellular Localization: Cytoplasm. Nucleus. Note=The myristoylated c-ABL protein is reported to be nuclear.

Protein Domain:
PDB:1AB2

The substrate proteins of kinase ABL1(Abl)

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ABL1ABL1_HUMANProto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1). 3Show
2ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 1Show
3BCRBCR_HUMANBreakpoint cluster region protein (EC 2.7.11.1) (Renal carcinomaantigen NY-REN-26). 2Show
4BTKBTK_HUMANTyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK). 2Show
5CASP9CASP9_HUMANCaspase-9 precursor (EC 3.4.22.62) (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10]. 2Show
6CATCATA_HUMANCatalase (EC 1.11.1.6). 4Show
7CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 2Show
8CD19CD19_HUMANB-lymphocyte antigen CD19 precursor (Differentiation antigen CD19) (B-lymphocyte surface antigen B4) (Leu-12). 1Show
9CDK5CDK5_HUMANCell division protein kinase 5 (EC 2.7.11.22) (Cyclin-dependent kinase5) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)(Serine/threonine-protein kinase PSSALRE). 3Show
10CDKN1BCDN1B_HUMANCyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1). 1Show
11CRKLCRKL_HUMANCrk-like protein. 1Show
12CRKCRK_HUMANProto-oncogene C-crk (p38) (Adapter molecule crk). 3