Regulatory Network in Protein Phosphorylation
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Kinase: ABL2(ARG) v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

Group: TK      Family: Abl      

Description: v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

Gene Symbol: ABL2

Synonyms: ABLL, ARG

UniprotKB/SwissProt: ABL2_HUMAN (P42684)

Function: Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics.

Subcellular Localization: Cytoplasm.

Protein Domain:

The substrate proteins of kinase ABL2(ARG)

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CATCATA_HUMANCatalase (EC 1.11.1.6). 4Show
2CRKCRK_HUMANProto-oncogene C-crk (p38) (Adapter molecule crk). 1Show
3GPX1GPX1_HUMANGlutathione peroxidase 1 (EC 1.11.1.9) (GSHPx-1) (GPx-1) (Cellularglutathione peroxidase). 2Show
4SIVA1SIVA_HUMANApoptosis regulatory protein Siva (CD27-binding protein) (CD27BP). 2Show



The substrate proteins of kinase family Abl

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ABL1ABL1_HUMANProto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1). 3Show
2ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 1Show
3BCRBCR_HUMANBreakpoint cluster region protein (EC 2.7.11.1) (Renal carcinomaantigen NY-REN-26). 2Show
4BTKBTK_HUMANTyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK). 2Show
5CASP9CASP9_HUMANCaspase-9 precursor (EC 3.4.22.62) (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10]. 2Show
6CATCATA_HUMANCatalase (EC 1.11.1.6). 4Show
7CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 2Show
8CD19CD19_HUMANB-lymphocyte antigen CD19 precursor (Differentiation antigen CD19) (B-lymphocyte surface antigen B4) (Leu-12). 1Show
9CDK5CDK5_HUMANCell division protein kinase 5 (EC 2.7.11.22) (Cyclin-dependent kinase5) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)(Serine/threonine-protein kinase PSSALRE). 3Show
10CDKN1BCDN1B_HUMANCyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1). 1Show
11CRKLCRKL_HUMANCrk-like protein. 1Show
12CRKCRK_HUMANProto-oncogene C-crk (p38) (Adapter molecule crk). 3Show
13DCXDCX_HUMANNeuronal migration protein doublecortin (Lissencephalin-X) (Lis-X)(Doublin). 1Show
14GPX1GPX1_HUMANGlutathione peroxidase 1 (EC 1.11.1.9) (GSHPx-1) (GPx-1) (Cellularglutathione peroxidase). 3Show
15NFKBIAIKBA_HUMANNF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer-binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IkB-alpha). 1Show
16JAK2JAK2_HUMANTyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2). 1Show
17JUNJUN_HUMANTranscription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogenec-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). 1Show
18PRKD1KPCD1_HUMANSerine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Proteinkinase D) (Protein kinase C mu type) (nPKC-mu). 5Show
19MAP4K1M4K1_HUMANMitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1)(MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)(Hematopoietic progenitor kinase). 1Show
20MDM2MDM2_HUMANE3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-) (p53-binding proteinMdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2). 2Show
21MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 1Show
22TP73P73_HUMANTumor protein p73 (p53-like transcription factor) (p53-relatedprotein). 3Show
23PLSCR1PLS1_HUMANPhospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependentphospholipid scramblase 1) (Erythrocyte phospholipid scramblase)(MmTRA1b). 6Show
24PLSCR4PLS4_HUMANPhospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependentphospholipid scramblase 4) (TRA1) (Cell growth-inhibiting gene 43protein). 4Show
25PSTPIP1PPIP1_HUMANProline-serine-threonine phosphatase-interacting protein 1 (PESTphosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP). 2Show
26PTPN6PTN6_HUMANTyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cellprotein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphataseSHP-1). 2Show
27RAD51RAD51_HUMANDNA repair protein RAD51 homolog 1 (hRAD51) (HsRAD51). 4Show
28RAD52RAD52_HUMANDNA repair protein RAD52 homolog. 2Show
29RAD9ARAD9A_HUMANCell cycle checkpoint control protein RAD9A (EC 3.1.11.2) (DNA repairexonuclease rad9 homolog A) (hRAD9). 2Show
30ROBO1ROBO1_HUMANRoundabout homolog 1 precursor (H-Robo-1) (Deleted in U twentytwenty). 3Show
31SIVA1SIVA_HUMANApoptosis regulatory protein Siva (CD27-binding protein) (CD27BP). 2Show
32MAPTTAU_HUMANMicrotubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau) (PHF-tau). 1Show
33TOP1TOP1_HUMANDNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I). 1Show
34WASF2WASF2_HUMANWiskott-Aldrich syndrome protein family member 2 (WASP family proteinmember 2) (Protein WAVE-2) (Verprolin homology domain-containingprotein 2). 1Show
35WASLWASL_HUMANNeural Wiskott-Aldrich syndrome protein (N-WASP). 2Show