Regulatory Network in Protein Phosphorylation
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Kinase: ACK tyrosine kinase, non-receptor, 2

Group: TK      Family: Ack      

Description: tyrosine kinase, non-receptor, 2

Gene Symbol: TNK2

Synonyms: ACK, ACK1, FLJ44758, FLJ45547, p21cdc42Hs

UniprotKB/SwissProt: ACK1_HUMAN (Q07912)

Function: Downstream effector of CDC42 which mediates CDC42- dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.

Subcellular Localization: Cell membrane (By similarity).

Protein Domain:
PDB:1CF4

The substrate proteins of kinase ACK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1TNK2ACK1_HUMANActivated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non-receptor protein 2). 1Show



The substrate proteins of kinase family Ack

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1TNK2ACK1_HUMANActivated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non-receptor protein 2). 1Show