|Group: TK Family: Ack |
Description: tyrosine kinase, non-receptor, 2
Gene Symbol: TNK2
Synonyms: ACK, ACK1, FLJ44758, FLJ45547, p21cdc42Hs
UniprotKB/SwissProt: ACK1_HUMAN (Q07912)
Function: Downstream effector of CDC42 which mediates CDC42- dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.
Subcellular Localization: Cell membrane (By similarity).