Regulatory Network in Protein Phosphorylation
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Kinase: CSK c-src tyrosine kinase

Group: TK      Family: Csk      

Description: c-src tyrosine kinase

Gene Symbol: CSK

Synonyms: MGC117393

UniprotKB/SwissProt: CSK_HUMAN (P41240)

Function: Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.

Subcellular Localization: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Mainly cytoplasmic, also present in lipid rafts (By similarity).

Protein Domain:
PDB:1BYG

The substrate proteins of kinase CSK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ARANDR_HUMANAndrogen receptor (Dihydrotestosterone receptor) (Nuclear receptorsubfamily 3 group C member 4). 11Show
2PTPRCCD45_HUMANLeukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (T200) (CD45antigen). 1Show
3CSKCSK_HUMANTyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein-tyrosine kinase CYL). 1Show
4CTNNB1CTNB1_HUMANCatenin beta-1 (Beta-catenin). 2Show
5FGRFGR_HUMANProto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C-FGR). 2Show
6FYNFYN_HUMANProto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn)(Protooncogene Syn) (SLK). 2Show
7GSNGELS_HUMANGelsolin precursor (Actin-depolymerizing factor) (ADF) (Brevin)(AGEL). 5Show
8HCKHCK_HUMANTyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK)(Hemopoietic cell kinase). 1Show
9LCKLCK_HUMANProto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK)(Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase). 1Show
10LYNLYN_HUMANTyrosine-protein kinase Lyn (EC 2.7.10.2). 2Show
11MAPK15MK15_HUMANMitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 8). 2Show
12MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 1Show
13PXNPAXI_HUMANPaxillin. 2Show
14PIP5K1CPI51C_HUMANPhosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68)(Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P-5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma). 1Show
15RGS16RGS16_HUMANRegulator of G-protein signaling 16 (RGS16) (Retinally abundantregulator of G-protein signaling) (RGS-R) (A28-RGS14P). 1Show
16SRCSRC_HUMANProto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src). 4Show



The substrate proteins of kinase family Csk

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ARANDR_HUMANAndrogen receptor (Dihydrotestosterone receptor) (Nuclear receptorsubfamily 3 group C member 4). 11Show
2PTPRCCD45_HUMANLeukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (T200) (CD45antigen). 1Show
3CSKCSK_HUMANTyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein-tyrosine kinase CYL). 1Show
4CTNNB1CTNB1_HUMANCatenin beta-1 (Beta-catenin). 2Show
5FGRFGR_HUMANProto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C-FGR). 2Show
6FYNFYN_HUMANProto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn)(Protooncogene Syn) (SLK). 2Show
7GSNGELS_HUMANGelsolin precursor (Actin-depolymerizing factor) (ADF) (Brevin)(AGEL). 5Show
8HCKHCK_HUMANTyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK)(Hemopoietic cell kinase). 1Show
9LCKLCK_HUMANProto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK)(Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase). 1Show
10LYNLYN_HUMANTyrosine-protein kinase Lyn (EC 2.7.10.2). 2Show
11MAPK15MK15_HUMANMitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 8). 2Show
12MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 1Show
13PXNPAXI_HUMANPaxillin. 2Show
14PIP5K1CPI51C_HUMANPhosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68)(Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P-5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma). 1Show
15RGS16RGS16_HUMANRegulator of G-protein signaling 16 (RGS16) (Retinally abundantregulator of G-protein signaling) (RGS-R) (A28-RGS14P). 1Show
16SRCSRC_HUMANProto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src). 4Show