Regulatory Network in Protein Phosphorylation
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Kinase: EGFR epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

Group: TK      Family: EGFR      

Description: epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

Gene Symbol: EGFR

Synonyms: ERBB, ERBB1, mENA

UniprotKB/SwissProt: EGFR_HUMAN (P00533)

Function: Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with C-SRC and CTNNB1/beta-catenin. Isoform 2/truncated isoform may act as an antagonist.

Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Protein Domain:
PDB:1DNQ

The substrate proteins of kinase EGFR

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1EPB4141_HUMANProtein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R). 4Show
2ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 2Show
3CALM1CALM_HUMANCalmodulin (CaM). 2Show
4CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 4Show
5CRKCRK_HUMANProto-oncogene C-crk (p38) (Adapter molecule crk). 2Show
6CTNND1CTND1_HUMANCatenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Srcsubstrate) (CAS) (p120(cas)). 1Show
7EGFREGFR_HUMANEpidermal growth factor receptor precursor (EC 2.7.10.1) (Receptortyrosine-protein kinase ErbB-1). 11Show
8EPS15EP15_HUMANEpidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1pprotein). 2Show
9ERBB2ERBB2_HUMANReceptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1)(p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cellsurface receptor HER2) (MLN 19) (CD340 antigen). 2Show
10VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 4Show
11GAB1GAB1_HUMANGRB2-associated-binding protein 1 (Growth factor receptor boundprotein 2-associated protein 1) (GRB2-associated binder 1). 18Show
12GRB2GRB2_HUMANGrowth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3adapter GRB2) (Protein Ash). 2Show
13HGSHGS_HUMANHepatocyte growth factor-regulated tyrosine kinase substrate (Proteinpp110) (Hrs). 2Show
14PKIAIPKA_HUMANcAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform). 2Show
15MYL9MLRN_HUMANMyosin regulatory light chain 2, smooth muscle isoform (Myosin RLC)(Myosin regulatory light chain 9) (LC20). 2Show
16MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 4Show
17PLCG1PLCG1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1)(Phospholipase C-gamma-1) (PLC-II) (PLC-148). 7Show
18PLD2PLD2_HUMANPhospholipase D2 (EC 3.1.4.4) (PLD 2) (Choline phosphatase 2)(Phosphatidylcholine-hydrolyzing phospholipase D2) (PLD1C) (hPLD2). 1Show
19PTPN1PTN1_HUMANTyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1B) (PTP-1B). 2Show
20RASA1RASA1_HUMANRas GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Rasp21 protein activator) (p120GAP) (RasGAP). 2Show
21RGS16RGS16_HUMANRegulator of G-protein signaling 16 (RGS16) (Retinally abundantregulator of G-protein signaling) (RGS-R) (A28-RGS14P). 4Show
22SCAMP1SCAM1_HUMANSecretory carrier-associated membrane protein 1 (Secretory carriermembrane protein 1). 1Show
23SCAMP3SCAM3_HUMANSecretory carrier-associated membrane protein 3 (Secretory carriermembrane protein 3). 1Show
24STAT5BSTA5B_HUMANSignal transducer and activator of transcription 5B. 8Show
25STAM2STAM2_HUMANSignal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein). 2Show
26STAT1STAT1_HUMANSignal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84). 3Show
27VAV2VAV2_HUMANProtein vav-2. 9Show



The substrate proteins of kinase family EGFR

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1EPB4141_HUMANProtein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R). 4Show
2ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 2Show
3CALM1CALM_HUMANCalmodulin (CaM). 2Show
4CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 4Show
5CRKCRK_HUMANProto-oncogene C-crk (p38) (Adapter molecule crk). 2Show
6CTNND1CTND1_HUMANCatenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Srcsubstrate) (CAS) (p120(cas)). 1Show
7EGFREGFR_HUMANEpidermal growth factor receptor precursor (EC 2.7.10.1) (Receptortyrosine-protein kinase ErbB-1). 11Show
8EPS15EP15_HUMANEpidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1pprotein). 2Show
9ERBB2ERBB2_HUMANReceptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1)(p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cellsurface receptor HER2) (MLN 19) (CD340 antigen). 2Show
10VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 4Show
11GAB1GAB1_HUMANGRB2-associated-binding protein 1 (Growth factor receptor boundprotein 2-associated protein 1) (GRB2-associated binder 1). 18Show
12GRB2GRB2_HUMANGrowth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3adapter GRB2) (Protein Ash). 2Show
13HGSHGS_HUMANHepatocyte growth factor-regulated tyrosine kinase substrate (Proteinpp110) (Hrs). 2Show
14PKIAIPKA_HUMANcAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform). 2Show
15MYL9MLRN_HUMANMyosin regulatory light chain 2, smooth muscle isoform (Myosin RLC)(Myosin regulatory light chain 9) (LC20). 2Show
16MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 4Show
17PLCG1PLCG1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1)(Phospholipase C-gamma-1) (PLC-II) (PLC-148). 7Show
18PLD2PLD2_HUMANPhospholipase D2 (EC 3.1.4.4) (PLD 2) (Choline phosphatase 2)(Phosphatidylcholine-hydrolyzing phospholipase D2) (PLD1C) (hPLD2). 1Show
19PTPN1PTN1_HUMANTyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1B) (PTP-1B). 2Show
20RASA1RASA1_HUMANRas GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Rasp21 protein activator) (p120GAP) (RasGAP). 2Show
21RGS16RGS16_HUMANRegulator of G-protein signaling 16 (RGS16) (Retinally abundantregulator of G-protein signaling) (RGS-R) (A28-RGS14P). 4Show
22SCAMP1SCAM1_HUMANSecretory carrier-associated membrane protein 1 (Secretory carriermembrane protein 1). 1Show
23SCAMP3SCAM3_HUMANSecretory carrier-associated membrane protein 3 (Secretory carriermembrane protein 3). 1Show
24STAT5BSTA5B_HUMANSignal transducer and activator of transcription 5B. 8Show
25STAM2STAM2_HUMANSignal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein). 2Show
26STAT1STAT1_HUMANSignal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84). 3Show
27VAV2VAV2_HUMANProtein vav-2. 9Show