|Group: TK Family: EGFR |
Description: epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Gene Symbol: EGFR
Synonyms: ERBB, ERBB1, mENA
UniprotKB/SwissProt: EGFR_HUMAN (P00533)
Function: Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with C-SRC and CTNNB1/beta-catenin. Isoform 2/truncated isoform may act as an antagonist.
Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.