Regulatory Network in Protein Phosphorylation
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Kinase: ErbB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

Group: TK      Family: EGFR      

Description: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

Gene Symbol: ERBB2

Synonyms: HER-2, HER-2/neu, HER2, NEU, NGL, TKR1, c-erb B2

UniprotKB/SwissProt: ERBB2_HUMAN (P04626)

Function: Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF- alpha and amphiregulin.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:
PDB:1N8Z