Regulatory Network in Protein Phosphorylation
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Kinase: ErbB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

Group: TK      Family: EGFR      

Description: v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

Gene Symbol: ERBB4

Synonyms: HER4, MGC138404, p180erbB4

UniprotKB/SwissProt: ERBB4_HUMAN (Q15303)

Function: Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:

The substrate proteins of kinase family EGFR

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1EPB4141_HUMANProtein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R). 4Show
2ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 2Show
3CALM1CALM_HUMANCalmodulin (CaM). 2Show
4CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 4Show
5CRKCRK_HUMANProto-oncogene C-crk (p38) (Adapter molecule crk). 2Show
6CTNND1CTND1_HUMANCatenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Srcsubstrate) (CAS) (p120(cas)). 1Show
7EGFREGFR_HUMANEpidermal growth factor receptor precursor (EC (Receptortyrosine-protein kinase ErbB-1). 11Show
8EPS15EP15_HUMANEpidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1pprotein). 2Show
9ERBB2ERBB2_HUMANReceptor tyrosine-protein kinase erbB-2 precursor (EC (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cellsurface receptor HER2) (MLN 19) (CD340 antigen). 2Show
10VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 4Show
11GAB1GAB1_HUMANGRB2-associated-binding protein 1 (Growth factor receptor boundprotein 2-associated protein 1) (GRB2-associated binder 1). 18Show
12GRB2GRB2_HUMANGrowth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3adapter GRB2) (Protein Ash). 2Show
13HGSHGS_HUMANHepatocyte growth factor-regulated tyrosine kinase substrate (Proteinpp110) (Hrs). 2Show
14PKIAIPKA_HUMANcAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform). 2Show
15MYL9MLRN_HUMANMyosin regulatory light chain 2, smooth muscle isoform (Myosin RLC)(Myosin regulatory light chain 9) (LC20). 2Show
16MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 4Show
17PLCG1PLCG1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1(EC (Phosphoinositide phospholipase C) (PLC-gamma-1)(Phospholipase C-gamma-1) (PLC-II) (PLC-148). 7Show
18PLD2PLD2_HUMANPhospholipase D2 (EC (PLD 2) (Choline phosphatase 2)(Phosphatidylcholine-hydrolyzing phospholipase D2) (PLD1C) (hPLD2). 1Show
19PTPN1PTN1_HUMANTyrosine-protein phosphatase non-receptor type 1 (EC phosphatase 1B) (PTP-1B). 2Show
20RASA1RASA1_HUMANRas GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Rasp21 protein activator) (p120GAP) (RasGAP). 2Show
21RGS16RGS16_HUMANRegulator of G-protein signaling 16 (RGS16) (Retinally abundantregulator of G-protein signaling) (RGS-R) (A28-RGS14P). 4Show
22SCAMP1SCAM1_HUMANSecretory carrier-associated membrane protein 1 (Secretory carriermembrane protein 1). 1Show
23SCAMP3SCAM3_HUMANSecretory carrier-associated membrane protein 3 (Secretory carriermembrane protein 3). 1Show
24STAT5BSTA5B_HUMANSignal transducer and activator of transcription 5B. 8Show
25STAM2STAM2_HUMANSignal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein). 2Show
26STAT1STAT1_HUMANSignal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84). 3Show
27VAV2VAV2_HUMANProtein vav-2. 9Show