Regulatory Network in Protein Phosphorylation
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Kinase: EphA3 EPH receptor A3

Group: TK      Family: Eph      

Description: EPH receptor A3

Gene Symbol: EPHA3

Synonyms: ETK, ETK1, HEK, HEK4, TYRO4

UniprotKB/SwissProt: EPHA3_HUMAN (P29320)

Function: Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.

Subcellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Protein Domain:

The substrate proteins of kinase EphA3

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1EPHA3EPHA3_HUMANEphrin type-A receptor 3 precursor (EC (Tyrosine-proteinkinase receptor ETK1) (HEK) (HEK4) (Tyrosine-protein kinase TYRO4). 6Show

The substrate proteins of kinase family Eph

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1CLDN4CLD4_HUMANClaudin-4 (Clostridium perfringens enterotoxin receptor) (CPE-receptor) (CPE-R) (Williams-Beuren syndrome chromosomal region 8protein). 1Show
2EFNB2EFNB2_HUMANEphrin-B2 precursor (EPH-related receptor tyrosine kinase ligand 5)(LERK-5) (HTK ligand) (HTK-L). 1Show
3EPHA3EPHA3_HUMANEphrin type-A receptor 3 precursor (EC (Tyrosine-proteinkinase receptor ETK1) (HEK) (HEK4) (Tyrosine-protein kinase TYRO4). 6Show
4EPHA4EPHA4_HUMANEphrin type-A receptor 4 precursor (EC (Tyrosine-proteinkinase receptor SEK) (Receptor protein-tyrosine kinase HEK8)(Tyrosine-protein kinase TYRO1). 4Show
5EPHA8EPHA8_HUMANEphrin type-A receptor 8 precursor (EC (Tyrosine-proteinkinase receptor EEK) (EPH- and ELK-related kinase) (HEK3). 4Show
6EPHB1EPHB1_HUMANEphrin type-B receptor 1 precursor (EC (Tyrosine-proteinkinase receptor EPH-2) (NET) (HEK6) (ELK). 2Show
7EPHB2EPHB2_HUMANEphrin type-B receptor 2 precursor (EC (Tyrosine-proteinkinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5)(ERK) (Tyrosine-protein kinase TYRO5) (Renal carcinoma antigen NY-REN-47). 2Show
8EPHB3EPHB3_HUMANEphrin type-B receptor 3 precursor (EC (Tyrosine-proteinkinase receptor HEK-2) (Tyrosine-protein kinase TYRO6). 2Show
9RRASRRAS_HUMANRas-related protein R-Ras precursor (p23). 2Show
10SDC3SDC3_HUMANSyndecan-3 (SYND3). 3Show