Regulatory Network in Protein Phosphorylation
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Kinase: FAK PTK2 protein tyrosine kinase 2

Group: TK      Family: FAK      

Description: PTK2 protein tyrosine kinase 2

Gene Symbol: PTK2

Synonyms: FADK, FAK, FAK1, pp125FAK

UniprotKB/SwissProt: FAK1_HUMAN (Q05397)

Function: Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Subcellular Localization: Cell junction, focal adhesion; Cytoplasmic side. Note=Constituent of focal adhesions.

Protein Domain:
PDB:1K04

The substrate proteins of kinase FAK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ACTN1ACTN1_HUMANAlpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-musclealpha-actinin-1) (F-actin cross-linking protein). 3Show
2BCAR1BCAR1_HUMANBreast cancer anti-estrogen resistance protein 1 (CRK-associatedsubstrate) (p130cas). 2Show
3BMXBMX_HUMANCytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrowtyrosine kinase gene in chromosome X protein) (Epithelial andendothelial tyrosine kinase) (ETK) (NTK38). 1Show
4PTK2FAK1_HUMANFocal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein-tyrosine kinase 2). 5Show
5PXNPAXI_HUMANPaxillin. 4Show
6SH3GL1SH3G1_HUMANEndophilin-A2 (Endophilin-2) (SH3 domain-containing GRB2-like protein1) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion geneprotein) (EEN) (EEN fusion partner of MLL). 1Show
7TGFB1I1TGFI1_HUMANTransforming growth factor beta-1-induced transcript 1 protein(Hydrogen peroxide-inducible clone 5 protein) (Hic-5) (Androgenreceptor-associated protein of 55 kDa). 1Show
8TRIOTRIO_HUMANTriple functional domain protein (EC 2.7.11.1) (PTPRF-interactingprotein). 1Show



The substrate proteins of kinase family FAK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ACTN1ACTN1_HUMANAlpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-musclealpha-actinin-1) (F-actin cross-linking protein). 3Show
2BCAR1BCAR1_HUMANBreast cancer anti-estrogen resistance protein 1 (CRK-associatedsubstrate) (p130cas). 2Show
3BMXBMX_HUMANCytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrowtyrosine kinase gene in chromosome X protein) (Epithelial andendothelial tyrosine kinase) (ETK) (NTK38). 1Show
4PTK2FAK1_HUMANFocal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein-tyrosine kinase 2). 5Show
5PXNPAXI_HUMANPaxillin. 4Show
6SH3GL1SH3G1_HUMANEndophilin-A2 (Endophilin-2) (SH3 domain-containing GRB2-like protein1) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion geneprotein) (EEN) (EEN fusion partner of MLL). 1Show
7TGFB1I1TGFI1_HUMANTransforming growth factor beta-1-induced transcript 1 protein(Hydrogen peroxide-inducible clone 5 protein) (Hic-5) (Androgenreceptor-associated protein of 55 kDa). 1Show
8TRIOTRIO_HUMANTriple functional domain protein (EC 2.7.11.1) (PTPRF-interactingprotein). 1Show