Regulatory Network in Protein Phosphorylation
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Kinase: PYK2 PTK2B protein tyrosine kinase 2 beta

Group: TK      Family: FAK      

Description: PTK2B protein tyrosine kinase 2 beta

Gene Symbol: PTK2B

Synonyms: CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK

UniprotKB/SwissProt: FAK2_HUMAN (Q14289)

Function: Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.

Subcellular Localization: Cytoplasm. Cell membrane. Note=Interaction with nephrocystin induces the membrane-association of the kinase.

Protein Domain:
PDB:2FO6

The substrate proteins of kinase PYK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1PTK2FAK1_HUMANFocal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein-tyrosine kinase 2). 1Show
2PTK2BFAK2_HUMANProtein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2)(FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta)(CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Relatedadhesion focal tyrosine kinase) (RAFTK). 7Show
3SNCASYUA_HUMANAlpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 componentof amyloid precursor) (NACP). 1Show



The substrate proteins of kinase family FAK

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ACTN1ACTN1_HUMANAlpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-musclealpha-actinin-1) (F-actin cross-linking protein). 3Show
2BCAR1BCAR1_HUMANBreast cancer anti-estrogen resistance protein 1 (CRK-associatedsubstrate) (p130cas). 2Show
3BMXBMX_HUMANCytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrowtyrosine kinase gene in chromosome X protein) (Epithelial andendothelial tyrosine kinase) (ETK) (NTK38). 1Show
4PTK2FAK1_HUMANFocal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein-tyrosine kinase 2). 5Show
5PXNPAXI_HUMANPaxillin. 4Show
6SH3GL1SH3G1_HUMANEndophilin-A2 (Endophilin-2) (SH3 domain-containing GRB2-like protein1) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion geneprotein) (EEN) (EEN fusion partner of MLL). 1Show
7TGFB1I1TGFI1_HUMANTransforming growth factor beta-1-induced transcript 1 protein(Hydrogen peroxide-inducible clone 5 protein) (Hic-5) (Androgenreceptor-associated protein of 55 kDa). 1Show
8TRIOTRIO_HUMANTriple functional domain protein (EC 2.7.11.1) (PTPRF-interactingprotein). 1Show