Regulatory Network in Protein Phosphorylation
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Kinase: FGFR4 fibroblast growth factor receptor 4

Group: TK      Family: FGFR      

Description: fibroblast growth factor receptor 4

Gene Symbol: FGFR4

Synonyms: CD334, JTK2, MGC20292, TKF

UniprotKB/SwissProt: FGFR4_HUMAN (P22455)

Function: Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:
PDB:1QCT

The substrate proteins of kinase FGFR4

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1FGFR4FGFR4_HUMANFibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4)(CD334 antigen). 2Show
2STAT1STAT1_HUMANSignal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84). 2Show
3STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 2Show



The substrate proteins of kinase family FGFR

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1BCAR1BCAR1_HUMANBreast cancer anti-estrogen resistance protein 1 (CRK-associatedsubstrate) (p130cas). 5Show
2FGFR1FGFR1_HUMANBasic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1)(FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331antigen). 11Show
3FGFR3FGFR3_HUMANFibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3)(CD333 antigen). 12Show
4FGFR4FGFR4_HUMANFibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4)(CD334 antigen). 2Show
5SYNCRIPHNRPQ_HUMANHeterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (hnRNP-Q)(Synaptotagmin-binding, cytoplasmic RNA-interacting protein) (Glycine-and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associatedprotein 1). 1Show
6RPS6KA3KS6A3_HUMANRibosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2)(RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAPkinase-activated protein kinase 1b) (MAPKAPK1B). 1Show
7PLCG1PLCG1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1)(Phospholipase C-gamma-1) (PLC-II) (PLC-148). 4Show
8CTTNSRC8_HUMANSrc substrate cortactin (Amplaxin) (Oncogene EMS1). 1Show
9STAT1STAT1_HUMANSignal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84). 4Show
10STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 4Show