Regulatory Network in Protein Phosphorylation
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Kinase: INSR insulin receptor

Group: TK      Family: InsR      

Description: insulin receptor

Gene Symbol: INSR

Synonyms: CD220, HHF5

UniprotKB/SwissProt: INSR_HUMAN (P06213)

Function: This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:
PDB:1GAG

The substrate proteins of kinase INSR

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ADRB2ADRB2_HUMANBeta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). 4Show
2BLVRABIEA_HUMANBiliverdin reductase A precursor (EC 1.3.1.24) (Biliverdin-IX alpha-reductase) (BVR A). 3Show
3CALM1CALM_HUMANCalmodulin (CaM). 2Show
4CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 5Show
5DOK1DOK1_HUMANDocking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62). 6Show
6FABP4FABP4_HUMANFatty acid-binding protein, adipocyte (AFABP) (Fatty acid-bindingprotein 4) (Adipocyte lipid-binding protein) (ALBP) (A-FABP). 1Show
7PTK2FAK1_HUMANFocal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein-tyrosine kinase 2). 2Show
8GAB1GAB1_HUMANGRB2-associated-binding protein 1 (Growth factor receptor boundprotein 2-associated protein 1) (GRB2-associated binder 1). 14Show
9INSRINSR_HUMANInsulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen)[Contains: Insulin receptor subunit alpha; Insulin receptor subunitbeta]. 15Show
10IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 8Show
11IRS2IRS2_HUMANInsulin receptor substrate 2 (IRS-2). 8Show
12PIK3R1P85A_HUMANPhosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K). 6Show
13PTPN1PTN1_HUMANTyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1B) (PTP-1B). 6Show
14PTPN6PTN6_HUMANTyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cellprotein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphataseSHP-1). 1Show
15SHC1SHC1_HUMANSHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2domain-containing-transforming protein C1). 2Show



The substrate proteins of kinase family InsR

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1ADRB2ADRB2_HUMANBeta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). 4Show
2BLVRABIEA_HUMANBiliverdin reductase A precursor (EC 1.3.1.24) (Biliverdin-IX alpha-reductase) (BVR A). 3Show
3CALM1CALM_HUMANCalmodulin (CaM). 2Show
4CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 5Show
5DOK1DOK1_HUMANDocking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62). 6Show
6FABP4FABP4_HUMANFatty acid-binding protein, adipocyte (AFABP) (Fatty acid-bindingprotein 4) (Adipocyte lipid-binding protein) (ALBP) (A-FABP). 1Show
7PTK2FAK1_HUMANFocal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein-tyrosine kinase 2). 2Show
8GAB1GAB1_HUMANGRB2-associated-binding protein 1 (Growth factor receptor boundprotein 2-associated protein 1) (GRB2-associated binder 1). 14Show
9INSRINSR_HUMANInsulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen)[Contains: Insulin receptor subunit alpha; Insulin receptor subunitbeta]. 15Show
10IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 8Show
11IRS2IRS2_HUMANInsulin receptor substrate 2 (IRS-2). 8Show
12PIK3R1P85A_HUMANPhosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K). 6Show
13PTPN1PTN1_HUMANTyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1B) (PTP-1B). 6Show
14PTPN6PTN6_HUMANTyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cellprotein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphataseSHP-1). 1Show
15SHC1SHC1_HUMANSHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2domain-containing-transforming protein C1). 2Show