Regulatory Network in Protein Phosphorylation
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Kinase: JAK2 Janus kinase 2 (a protein tyrosine kinase)

Group: TK      Family: JakA      

Description: Janus kinase 2 (a protein tyrosine kinase)

Gene Symbol: JAK2

Synonyms: -

UniprotKB/SwissProt: JAK2_HUMAN (O60674)

Function: Tyrosine kinase of the non-receptor type, involved in interleukin-3 and probably interleukin-23 signal transduction.

Subcellular Localization: Intracytoplasmic membrane; Peripheral membrane protein (By similarity). Note=Wholly intracellular, possibly membrane associated (By similarity).

Protein Domain:
PDB:2B7A

The substrate proteins of kinase JAK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1CCR2CCR2_HUMANC-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2)(Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD192antigen). 3Show
2CTLA4CTLA4_HUMANCytotoxic T-lymphocyte protein 4 precursor (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD152 antigen). 2Show
3EGFREGFR_HUMANEpidermal growth factor receptor precursor (EC 2.7.10.1) (Receptortyrosine-protein kinase ErbB-1). 1Show
4EPOREPOR_HUMANErythropoietin receptor precursor (EPO-R). 20Show
5GHRGHR_HUMANGrowth hormone receptor precursor (GH receptor) (Somatotropinreceptor) [Contains: Growth hormone-binding protein (GH-bindingprotein) (GHBP) (Serum-binding protein)]. 2Show
6GTF2IGTF2I_HUMANGeneral transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosinekinase-associated protein 135) (BTK-associated protein 135) (BAP-135)(SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndromechromosomal region 6 protein). 1Show
7JAK2JAK2_HUMANTyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2). 9Show
8LEPRLEPR_HUMANLeptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295antigen). 2Show
9SH2BQ9NRF2_HUMANSH2-B beta signaling protein (Putative uncharacterized proteinDKFZp727I201). 2Show
10RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf). 2Show
11SIRPASHPS1_HUMANTyrosine-protein phosphatase non-receptor type substrate 1 precursor(SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signalregulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha-3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-basedactivation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172aantigen). 1Show
12STAT5ASTA5A_HUMANSignal transducer and activator of transcription 5A. 2Show
13STAT1STAT1_HUMANSignal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84). 3Show
14STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 4Show