Regulatory Network in Protein Phosphorylation
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Kinase: JAK3 Janus kinase 3 (a protein tyrosine kinase, leukocyte)

Group: TK      Family: JakA      

Description: Janus kinase 3 (a protein tyrosine kinase, leukocyte)

Gene Symbol: JAK3

Synonyms: JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK

UniprotKB/SwissProt: JAK3_HUMAN (P52333)

Function: Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K.

Subcellular Localization: Intracytoplasmic membrane; Peripheral membrane protein (By similarity). Note=Wholly intracellular, possibly membrane associated (By similarity).

Protein Domain:
PDB:1YVJ

The substrate proteins of kinase JAK3

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1JAK1JAK1_HUMANTyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1). 4Show
2JAK3JAK3_HUMANTyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3)(Leukocyte janus kinase) (L-JAK). 6Show
3SIGLEC10SIG10_HUMANSialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec-like protein 2). 3Show