Regulatory Network in Protein Phosphorylation
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Kinase: TYK2 tyrosine kinase 2

Group: TK      Family: JakA      

Description: tyrosine kinase 2

Gene Symbol: TYK2

Synonyms: JTK1

UniprotKB/SwissProt: TYK2_HUMAN (P29597)

Function: Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Subcellular Localization:

Protein Domain:

The substrate proteins of kinase TYK2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1GNB2L1GBLP_HUMANGuanine nucleotide-binding protein subunit beta-2-like 1 (Guaninenucleotide-binding protein subunit beta-like protein 12.3) (Receptorof activated protein kinase C 1) (RACK1) (Receptor for activated Ckinase). 1Show
2IL10RAI10R1_HUMANInterleukin-10 receptor alpha chain precursor (IL-10R-A) (IL-10R1)(CDw210a antigen). 2Show
3IFNAR1INAR1_HUMANInterferon-alpha/beta receptor alpha chain precursor (IFN-alpha-REC). 6Show
4STAT1STAT1_HUMANSignal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84). 2Show
5TYK2TYK2_HUMANNon-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2). 2Show