Regulatory Network in Protein Phosphorylation
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Kinase: JAK1 Janus kinase 1 (a protein tyrosine kinase)

Group: TK      Family: JakA      

Description: Janus kinase 1 (a protein tyrosine kinase)

Gene Symbol: JAK1

Synonyms: JAK1A, JAK1B

UniprotKB/SwissProt: JAK1_HUMAN (P23458)

Function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

Subcellular Localization: Intracytoplasmic membrane; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.

Protein Domain:

The substrate proteins of kinase JAK1

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1IL10RAI10R1_HUMANInterleukin-10 receptor alpha chain precursor (IL-10R-A) (IL-10R1)(CDw210a antigen). 2Show
2IL2RBIL2RB_HUMANInterleukin-2 receptor subunit beta precursor (IL-2 receptor) (P70-75)(p75) (High affinity IL-2 receptor subunit beta) (CD122 antigen). 1Show
3IFNGR1INGR1_HUMANInterferon-gamma receptor alpha chain precursor (IFN-gamma-R1) (CD119antigen) (CDw119). 1Show
4IRS1IRS1_HUMANInsulin receptor substrate 1 (IRS-1). 4Show
5SH2BQ9NRF2_HUMANSH2-B beta signaling protein (Putative uncharacterized proteinDKFZp727I201). 2Show
6STAT5ASTA5A_HUMANSignal transducer and activator of transcription 5A. 1Show
7STAT5BSTA5B_HUMANSignal transducer and activator of transcription 5B. 1Show
8STAT1STAT1_HUMANSignal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84). 4Show
9STAT2STAT2_HUMANSignal transducer and activator of transcription 2 (p113). 2Show
10STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 3Show
11STAT4STAT4_HUMANSignal transducer and activator of transcription 4. 1Show
12STAT6STAT6_HUMANSignal transducer and activator of transcription 6 (IL-4 Stat). 1Show
13TYK2TYK2_HUMANNon-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2). 4Show