Regulatory Network in Protein Phosphorylation
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Kinase: KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Group: TK      Family: PDGFR      

Description: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Gene Symbol: KIT

Synonyms: C-Kit, CD117, SCFR

UniprotKB/SwissProt: KIT_HUMAN (P10721)

Function: This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:
PDB:1PKG

The substrate proteins of kinase KIT

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1KITKIT_HUMANMast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR)(Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen). 8Show
2STAT1STAT1_HUMANSignal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84). 1Show



The substrate proteins of kinase family PDGFR

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 2Show
2FYNFYN_HUMANProto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn)(Protooncogene Syn) (SLK). 2Show
3MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 2Show
4PDGFRAPGFRA_HUMANAlpha-type platelet-derived growth factor receptor precursor(EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen). 8Show
5PDGFRBPGFRB_HUMANBeta-type platelet-derived growth factor receptor precursor(EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen). 24Show
6PLCG1PLCG1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1)(Phospholipase C-gamma-1) (PLC-II) (PLC-148). 3Show
7PTPN11PTN11_HUMANTyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48)(Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH-PTP2) (SHP-2) (Shp2). 5Show
8SH2BQ9NRF2_HUMANSH2-B beta signaling protein (Putative uncharacterized proteinDKFZp727I201). 1Show
9RASA1RASA1_HUMANRas GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Rasp21 protein activator) (p120GAP) (RasGAP). 1Show
10SHC1SHC1_HUMANSHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2domain-containing-transforming protein C1). 1Show