Regulatory Network in Protein Phosphorylation
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Kinase: RET ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)

Group: TK      Family: Ret      

Description: ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)

Gene Symbol: RET

Synonyms: CDHF12, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51

UniprotKB/SwissProt: RET_HUMAN (P07949)

Function: Probable receptor with tyrosine-protein kinase activity; important for development.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:
PDB:1XPD

The substrate proteins of kinase RET

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1DOK1DOK1_HUMANDocking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62). 1Show
2PTK2FAK1_HUMANFocal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein-tyrosine kinase 2). 2Show
3MAPK1MK01_HUMANMitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1). 1Show
4MAPK8MK08_HUMANMitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activatedprotein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46). 1Show
5MAPK9MK09_HUMANMitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activatedprotein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55). 1Show
6MAPK14MK14_HUMANMitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activatedprotein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressiveanti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP)(MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A). 1Show
7PDPK1PDPK1_HUMAN3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1). 1Show
8PLCG1PLCG1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1)(Phospholipase C-gamma-1) (PLC-II) (PLC-148). 1Show
9RETRET_HUMANProto-oncogene tyrosine-protein kinase receptor ret precursor(EC 2.7.10.1) (C-ret). 26Show
10STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 1Show



The substrate proteins of kinase family Ret

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1DOK1DOK1_HUMANDocking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62). 1Show
2PTK2FAK1_HUMANFocal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein-tyrosine kinase 2). 2Show
3MAPK1MK01_HUMANMitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellularsignal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1). 1Show
4MAPK8MK08_HUMANMitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activatedprotein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46). 1Show
5MAPK9MK09_HUMANMitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activatedprotein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55). 1Show
6MAPK14MK14_HUMANMitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activatedprotein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressiveanti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP)(MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A). 1Show
7PDPK1PDPK1_HUMAN3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1). 1Show
8PLCG1PLCG1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1)(Phospholipase C-gamma-1) (PLC-II) (PLC-148). 1Show
9RETRET_HUMANProto-oncogene tyrosine-protein kinase receptor ret precursor(EC 2.7.10.1) (C-ret). 26Show
10STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 1Show