Regulatory Network in Protein Phosphorylation
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Kinase: FYN FYN oncogene related to SRC, FGR, YES

Group: TK      Family: Src      Subfamily: SrcA

Description: FYN oncogene related to SRC, FGR, YES

Gene Symbol: FYN

Synonyms: MGC45350, SLK, SYN

UniprotKB/SwissProt: FYN_HUMAN (P06241)

Function: Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.

Subcellular Localization: Cell membrane. Note=Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.

Protein Domain:
PDB:1A0N

The substrate proteins of kinase FYN

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1TNK2ACK1_HUMANActivated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non-receptor protein 2). 1Show
2CAV1CAV1_HUMANCaveolin-1. 1Show
3CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 4Show
4CD247CD3Z_HUMANT-cell surface glycoprotein CD3 zeta chain precursor (T-cell receptorT3 zeta chain) (CD247 antigen). 2Show
5CD5CD5_HUMANT-cell surface glycoprotein CD5 precursor (Lymphocyte antigen T1/Leu-1) (CD5 antigen). 2Show
6CD79ACD79A_HUMANB-cell antigen receptor complex-associated protein alpha-chainprecursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM-associated protein) (Membrane-bound immunoglobulin-associated protein)(CD79a antigen). 2Show
7CD79BCD79B_HUMANB-cell antigen receptor complex-associated protein beta-chainprecursor (B-cell-specific glycoprotein B29) (Immunoglobulin-associated B29 protein) (IG-beta) (CD79b antigen). 4Show
8CDK5CDK5_HUMANCell division protein kinase 5 (EC 2.7.11.22) (Cyclin-dependent kinase5) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)(Serine/threonine-protein kinase PSSALRE). 1Show
9CD300LBCLM7_HUMANCMRF35-like molecule 7 precursor (CLM-7) (CMRF35-A2) (CD300 antigen-like family member B) (Immune receptor expressed on myeloid cells 3)(IREM-3) (Triggering receptor expressed on myeloid cells 5) (TREM-5)(Leukocyte mono-Ig-like receptor 5) (CD300b antigen). 1Show
10CNN3CNN3_HUMANCalponin-3 (Calponin, acidic isoform). 1Show
11CTLA4CTLA4_HUMANCytotoxic T-lymphocyte protein 4 precursor (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD152 antigen). 1Show
12CTNNB1CTNB1_HUMANCatenin beta-1 (Beta-catenin). 2Show
13FCGR2AFCG2A_HUMANLow affinity immunoglobulin gamma Fc region receptor II-a precursor(Fc-gamma RII-a) (FcRII-a) (IgG Fc receptor II-a) (Fc-gamma-RIIa)(CD32 antigen) (CDw32). 6Show
14FYBFYB_HUMANFYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130)(SLP-76-associated phosphoprotein) (SLAP-130) (Adhesion anddegranulation promoting adaptor protein) (ADAP). 4Show
15FYNFYN_HUMANProto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn)(Protooncogene Syn) (SLK). 7Show
16GRB10GRB10_HUMANGrowth factor receptor-bound protein 10 (GRB10 adaptor protein)(Insulin receptor-binding protein GRB-IR). 2Show
17ITCHITCH_HUMANE3 ubiquitin-protein ligase Itchy homolog (EC 6.3.2.-) (Itch)(Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide1) (NAPP1). 1Show
18ITPR1ITPR1_HUMANInositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform1) (InsP3R1) (IP3R). 2Show
19MAP2MAP2_HUMANMicrotubule-associated protein 2 (MAP 2) (MAP-2). 1Show
20GRIN2BNMDE2_HUMANGlutamate [NMDA] receptor subunit epsilon-2 precursor (N-methyl D-aspartate receptor subtype 2B) (NR2B) (NMDAR2B) (N-methyl-D-aspartatereceptor subunit 3) (NR3) (hNR3). 7Show
21NMT1NMT1_HUMANGlycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Peptide N-myristoyltransferase 1) (Myristoyl-CoA:protein N-myristoyltransferase1) (NMT 1) (Type I N-myristoyltransferase). 2Show
22PAG1PAG1_HUMANPhosphoprotein associated with glycosphingolipid-enriched microdomains1 (Transmembrane adapter protein PAG) (Csk-binding protein)(Transmembrane phosphoprotein Cbp). 1Show
23JUPPLAK_HUMANJunction plakoglobin (Desmoplakin-3) (Desmoplakin III) (Cateningamma). 2Show
24PLCG2PLCG2_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2)(Phospholipase C-gamma-2) (PLC-IV). 5Show
25ACP1PPAC_HUMANLow molecular weight phosphotyrosine protein phosphatase (EC 3.1.3.48)(LMW-PTPase) (LMW-PTP) (Low molecular weight cytosolic acidphosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1) (Adipocyteacid phosphatase). 2Show
26SHC1SHC1_HUMANSHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2domain-containing-transforming protein C1). 2Show
27SKAP1SKAP1_HUMANSrc kinase-associated phosphoprotein 1 (Src family-associatedphosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa)(pp55) (SKAP-55). 4Show
28SLAMF1SLAF1_HUMANSignaling lymphocytic activation molecule precursor (IPO-3) (CD150antigen) (CDw150). 6Show
29SNCASYUA_HUMANAlpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 componentof amyloid precursor) (NACP). 1Show
30SNX26TCGAP_HUMANTC10/CDC42 GTPase-activating protein (Sorting nexin-26). 1Show
31TGFB1I1TGFI1_HUMANTransforming growth factor beta-1-induced transcript 1 protein(Hydrogen peroxide-inducible clone 5 protein) (Hic-5) (Androgenreceptor-associated protein of 55 kDa). 2Show
32TOM1L1TM1L1_HUMANTOM1-like protein 1 (Target of Myb-like protein 1) (Src-activating andsignaling molecule protein). 1Show
33TXKTXK_HUMANTyrosine-protein kinase TXK (EC 2.7.10.2). 1Show