Regulatory Network in Protein Phosphorylation
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Kinase: LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Group: TK      Family: Src      Subfamily: SrcB

Description: v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Gene Symbol: LYN

Synonyms: FLJ26625, JTK8

UniprotKB/SwissProt: LYN_HUMAN (P07948)

Function:

Subcellular Localization:

Protein Domain:
PDB:1W1F

The substrate proteins of kinase LYN

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1SLC4A1B3AT_HUMANBand 3 anion transport protein (Anion exchange protein 1) (AE 1)(Solute carrier family 4 member 1) (CD233 antigen). 8Show
2BTKBTK_HUMANTyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK). 2Show
3CD19CD19_HUMANB-lymphocyte antigen CD19 precursor (Differentiation antigen CD19) (B-lymphocyte surface antigen B4) (Leu-12). 5Show
4CD79ACD79A_HUMANB-cell antigen receptor complex-associated protein alpha-chainprecursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM-associated protein) (Membrane-bound immunoglobulin-associated protein)(CD79a antigen). 2Show
5CD79BCD79B_HUMANB-cell antigen receptor complex-associated protein beta-chainprecursor (B-cell-specific glycoprotein B29) (Immunoglobulin-associated B29 protein) (IG-beta) (CD79b antigen). 4Show
6CDC2CDC2_HUMANCell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23)(p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1). 2Show
7CDKN1BCDN1B_HUMANCyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1). 1Show
8CSNK2A1CSK21_HUMANCasein kinase II subunit alpha (EC 2.7.11.1) (CK II). 1Show
9DAPP1DAPP1_HUMANDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B-cell adapter molecule of 32 kDa) (Blymphocyte adapter protein Bam32). 1Show
10EPOREPOR_HUMANErythropoietin receptor precursor (EPO-R). 1Show
11FCGR2AFCG2A_HUMANLow affinity immunoglobulin gamma Fc region receptor II-a precursor(Fc-gamma RII-a) (FcRII-a) (IgG Fc receptor II-a) (Fc-gamma-RIIa)(CD32 antigen) (CDw32). 6Show
12FCGR2BFCG2B_HUMANLow affinity immunoglobulin gamma Fc region receptor II-b precursor(Fc-gamma RII-b) (FcRII-b) (IgG Fc receptor II-b) (Fc-gamma-RIIb)(CD32 antigen) (CDw32). 2Show
13FCGR2CFCG2C_HUMANLow affinity immunoglobulin gamma Fc region receptor II-c precursor(Fc-gamma RII-c) (FcRII-c) (IgG Fc receptor II-c) (Fc-gamma-RIIc)(CD32 antigen) (CDw32). 1Show
14HCLS1HCLS1_HUMANHematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75). 6Show
15PRKCDKPCD_HUMANProtein kinase C delta type (EC 2.7.11.13) (nPKC-delta). 5Show
16SYKKSYK_HUMANTyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase). 2Show
17LYNLYN_HUMANTyrosine-protein kinase Lyn (EC 2.7.10.2). 2Show
18MAP4K1M4K1_HUMANMitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1)(MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)(Hematopoietic progenitor kinase). 1Show
19MAP2MAP2_HUMANMicrotubule-associated protein 2 (MAP 2) (MAP-2). 1Show
20MISTMIST_HUMANMast cell immunoreceptor signal transducer (Cytokine-dependenthematopoietic cell linker). 2Show
21NMT1NMT1_HUMANGlycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Peptide N-myristoyltransferase 1) (Myristoyl-CoA:protein N-myristoyltransferase1) (NMT 1) (Type I N-myristoyltransferase). 3Show
22PLCG1PLCG1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1)(Phospholipase C-gamma-1) (PLC-II) (PLC-148). 2Show
23PLCG2PLCG2_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2)(Phospholipase C-gamma-2) (PLC-IV). 5Show
24PPP1R8PP1R8_HUMANNuclear inhibitor of protein phosphatase 1 (NIPP-1) (Proteinphosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator ofRNA decay (EC 3.1.4.-) (ARD-1)]. 5Show
25PTPN6PTN6_HUMANTyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cellprotein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphataseSHP-1). 1Show
26RGS16RGS16_HUMANRegulator of G-protein signaling 16 (RGS16) (Retinally abundantregulator of G-protein signaling) (RGS-R) (A28-RGS14P). 2Show
27SLAMF1SLAF1_HUMANSignaling lymphocytic activation molecule precursor (IPO-3) (CD150antigen) (CDw150). 1Show
28STAT5ASTA5A_HUMANSignal transducer and activator of transcription 5A. 1Show
29SNCASYUA_HUMANAlpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 componentof amyloid precursor) (NACP). 1Show
30TRPV4TRPV4_HUMANTransient receptor potential cation channel subfamily V member 4(TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-likechannel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloidreceptor-related osmotically-activated channel) (VR-OAC) (Transientreceptor potential protein 12) (TRP12). 2Show