Regulatory Network in Protein Phosphorylation
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Kinase: SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

Group: TK      Family: Src      Subfamily: SrcA

Description: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

Gene Symbol: SRC

Synonyms: ASV, SRC1, c-SRC, p60-Src

UniprotKB/SwissProt: SRC_HUMAN (P12931)

Function:

Subcellular Localization:

Protein Domain:
PDB:1A07

The substrate proteins of kinase SRC

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1HLA-A1A01_HUMANHLA class I histocompatibility antigen, A-1 alpha chain precursor (MHCclass I antigen A*1). 1Show
2HLA-B1B07_HUMANHLA class I histocompatibility antigen, B-7 alpha chain precursor (MHCclass I antigen B*7). 1Show
3ABL1ABL1_HUMANProto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1). 5Show
4CHRNA7ACHA7_HUMANNeuronal acetylcholine receptor subunit alpha-7 precursor. 2Show
5ADAM12ADA12_HUMANADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinasedomain 12) (Meltrin-alpha). 1Show
6ADAM15ADA15_HUMANADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinasedomain 15) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein)(Metargidin). 2Show
7AKT1AKT1_HUMANRAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha)(Protein kinase B) (PKB) (C-AKT). 2Show
8ANXA1ANXA1_HUMANAnnexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein). 2Show
9ANXA2ANXA2_HUMANAnnexin A2 (Annexin-2) (Annexin II) (Lipocortin II) (Calpactin I heavychain) (Chromobindin-8) (p36) (Protein I) (Placental anticoagulantprotein IV) (PAP-IV). 2Show
10ARAFARAF_HUMANA-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A-raf-1) (Proto-oncogene Pks). 2Show
11ATP2B4AT2B4_HUMANPlasma membrane calcium-transporting ATPase 4 (EC 3.6.3.8) (PMCA4)(Plasma membrane calcium pump isoform 4) (Plasma membrane calciumATPase isoform 4) (Matrix-remodeling-associated protein 1). 2Show
12BCAR1BCAR1_HUMANBreast cancer anti-estrogen resistance protein 1 (CRK-associatedsubstrate) (p130cas). 11Show
13BDKRB2BKRB2_HUMANB2 bradykinin receptor (BK-2 receptor) (B2R). 2Show
14BMXBMX_HUMANCytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrowtyrosine kinase gene in chromosome X protein) (Epithelial andendothelial tyrosine kinase) (ETK) (NTK38). 2Show
15CDH2CADH2_HUMANCadherin-2 precursor (Neural cadherin) (N-cadherin) (CD325 antigen)(CDw325). 2Show
16CAV1CAV1_HUMANCaveolin-1. 2Show
17CAV2CAV2_HUMANCaveolin-2. 2Show
18CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 2Show
19CD33CD33_HUMANMyeloid cell surface antigen CD33 precursor (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67). 2Show
20CD79ACD79A_HUMANB-cell antigen receptor complex-associated protein alpha-chainprecursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM-associated protein) (Membrane-bound immunoglobulin-associated protein)(CD79a antigen). 1Show
21CDC42CDC42_HUMANCell division control protein 42 homolog precursor (G25K GTP-bindingprotein). 1Show
22CDCP1CDCP1_HUMANCUB domain-containing protein 1 precursor (Transmembrane andassociated with src kinases) (Membrane glycoprotein gp140)(Subtractive immunization M plus HEp3-associated 135 kDa protein)(SIMA135) (CD318 antigen). 1Show
23CEACAM1CEAM1_HUMANCarcinoembryonic antigen-related cell adhesion molecule 1 precursor(Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen). 2Show
24CLTCCLH1_HUMANClathrin heavy chain 1 (CLH-17). 1Show
25CTNNB1CTNB1_HUMANCatenin beta-1 (Beta-catenin). 4Show
26CTNND1CTND1_HUMANCatenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Srcsubstrate) (CAS) (p120(cas)). 8Show
27GJA1CXA1_HUMANGap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDaheart protein). 2Show
28DAB1DAB1_HUMANDisabled homolog 1. 5Show
29DAG1DAG1_HUMANDystroglycan precursor (Dystrophin-associated glycoprotein 1)[Contains: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]. 2Show
30DAPP1DAPP1_HUMANDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B-cell adapter molecule of 32 kDa) (Blymphocyte adapter protein Bam32). 1Show
31DDR2DDR2_HUMANDiscoidin domain-containing receptor 2 precursor (EC 2.7.10.1)(Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT)(Tyrosine-protein kinase TYRO10) (Neurotrophic tyrosine kinase,receptor-related 3) (CD167b antigen). 2Show
32DNM1DYN1_HUMANDynamin-1 (EC 3.6.5.5). 2Show
33EFSEFS_HUMANEmbryonal Fyn-associated substrate (HEFS). 1Show
34EGFREGFR_HUMANEpidermal growth factor receptor precursor (EC 2.7.10.1) (Receptortyrosine-protein kinase ErbB-1). 9Show
35ENO1ENOA_HUMANAlpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Non-neural enolase) (NNE) (Enolase 1) (Phosphopyruvate hydratase) (C-mycpromoter-binding protein) (MBP-1) (MPB-1) (Plasminogen-bindingprotein). 1Show
36ESR1ESR1_HUMANEstrogen receptor (ER) (Estradiol receptor) (ER-alpha) (Nuclearreceptor subfamily 3 group A member 1). 2Show
37VIL2EZRI_HUMANEzrin (p81) (Cytovillin) (Villin-2). 1Show
38PTK2FAK1_HUMANFocal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein-tyrosine kinase 2). 7Show
39FHITFHIT_HUMANBis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (Diadenosine 5',5'''-P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (AP3Ahydrolase) (AP3Aase) (Fragile histidine triad protein). 2Show
40GASTGAST_HUMANGastrin precursor [Contains: Gastrin-71 (Gastrin component I);Gastrin-52 (G52); Big gastrin (Gastrin-34) (G34) (Gastrin componentII); Gastrin (Gastrin-17) (G17) (Gastrin component III); Gastrin-14(G14); Gastrin-6 (G6)]. 1Show
41GNB2L1GBLP_HUMANGuanine nucleotide-binding protein subunit beta-2-like 1 (Guaninenucleotide-binding protein subunit beta-like protein 12.3) (Receptorof activated protein kinase C 1) (RACK1) (Receptor for activated Ckinase). 2Show
42GSNGELS_HUMANGelsolin precursor (Actin-depolymerizing factor) (ADF) (Brevin)(AGEL). 6Show
43GNAT1GNAT1_HUMANGuanine nucleotide-binding protein G(t) subunit alpha-1 (Transducinalpha-1 chain). 1Show
44GRB10GRB10_HUMANGrowth factor receptor-bound protein 10 (GRB10 adaptor protein)(Insulin receptor-binding protein GRB-IR). 2Show
45GRB2GRB2_HUMANGrowth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3adapter GRB2) (Protein Ash). 1Show
46GRLF1GRLF1_HUMANGlucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptorrepression factor 1) (GRF-1) (Rho GAP p190A) (p190-A). 2Show
47GTF2IGTF2I_HUMANGeneral transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosinekinase-associated protein 135) (BTK-associated protein 135) (BAP-135)(SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndromechromosomal region 6 protein). 3Show
48HNRPKHNRPK_HUMANHeterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformationup-regulated nuclear protein) (TUNP). 9Show
49IGF1RIGF1R_HUMANInsulin-like growth factor 1 receptor precursor (EC 2.7.10.1)(Insulin-like growth factor I receptor) (IGF-I receptor) (CD221antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain;Insulin-like growth factor 1 receptor beta chain]. 8Show
50NFKBIAIKBA_HUMANNF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer-binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IkB-alpha). 2Show
51ITGB3ITB3_HUMANIntegrin beta-3 precursor (Platelet membrane glycoprotein IIIa)(GPIIIa) (CD61 antigen). 4Show
52KCNA3KCNA3_HUMANPotassium voltage-gated channel subfamily A member 3 (Voltage-gatedpotassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). 2Show
53KCNB1KCNB1_HUMANPotassium voltage-gated channel subfamily B member 1 (Voltage-gatedpotassium channel subunit Kv2.1) (h-DRK1). 1Show
54KITKIT_HUMANMast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR)(Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen). 2Show
55PRKD1KPCD1_HUMANSerine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Proteinkinase D) (Protein kinase C mu type) (nPKC-mu). 3Show
56PRKCIKPCI_HUMANProtein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypicalprotein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota). 9Show
57LRP1LRP1_HUMANProlow-density lipoprotein receptor-related protein 1 precursor (LRP)(Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor)(APOER) (CD91 antigen) [Contains: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoproteinreceptor-related protein 1 515 kDa subunit (LRP-515); Low-densitylipoprotein receptor-related protein 1 intracellular domain (LRPICD)]. 2Show
58MPZL1MPZL1_HUMANMyelin protein zero-like protein 1 precursor (Protein zero-related). 4Show
59MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 2Show
60GRIN2ANMDE1_HUMANGlutamate [NMDA] receptor subunit epsilon-1 precursor (N-methyl D-aspartate receptor subtype 2A) (NR2A) (NMDAR2A) (hNR2A). 3Show
61GRIN2BNMDE2_HUMANGlutamate [NMDA] receptor subunit epsilon-2 precursor (N-methyl D-aspartate receptor subtype 2B) (NR2B) (NMDAR2B) (N-methyl-D-aspartatereceptor subunit 3) (NR3) (hNR3). 1Show
62PIK3R1P85A_HUMANPhosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K). 1Show
63PAK2PAK2_HUMANSerine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activatedkinase 2) (PAK-2) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p58) [Contains:PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]. 2Show
64PXNPAXI_HUMANPaxillin. 4Show
65PDPK1PDPK1_HUMAN3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1). 6Show
66JUPPLAK_HUMANJunction plakoglobin (Desmoplakin-3) (Desmoplakin III) (Cateningamma). 1Show
67PLCG1PLCG1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1)(Phospholipase C-gamma-1) (PLC-II) (PLC-148). 1Show
68PLCG2PLCG2_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2)(Phospholipase C-gamma-2) (PLC-IV). 2Show
69PLSCR1PLS1_HUMANPhospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependentphospholipid scramblase 1) (Erythrocyte phospholipid scramblase)(MmTRA1b). 2Show
70PTPN6PTN6_HUMANTyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cellprotein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphataseSHP-1). 2Show
71PTPRAPTPRA_HUMANReceptor-type tyrosine-protein phosphatase alpha precursor(EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha). 1Show
72RAF1RAF1_HUMANRAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf). 2Show
73RGS16RGS16_HUMANRegulator of G-protein signaling 16 (RGS16) (Retinally abundantregulator of G-protein signaling) (RGS-R) (A28-RGS14P). 3Show
74RAPGEF1RPGF1_HUMANRap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasingfactor 2) (C3G protein) (CRK SH3-binding GNRP). 1Show
75RRASRRAS_HUMANRas-related protein R-Ras precursor (p23). 1Show
76SH3GL1SH3G1_HUMANEndophilin-A2 (Endophilin-2) (SH3 domain-containing GRB2-like protein1) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion geneprotein) (EEN) (EEN fusion partner of MLL). 1Show
77SHC1SHC1_HUMANSHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2domain-containing-transforming protein C1). 4Show
78INPPL1SHIP2_HUMANPhosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.n1)(SH2 domain-containing inositol-5'-phosphatase 2) (SHIP-2) (Inositolpolyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C). 3Show
79SPTAN1SPTA2_HUMANSpectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)(Alpha-II spectrin) (Fodrin alpha chain). 2Show
80SPRY2SPY2_HUMANProtein sprouty homolog 2 (Spry-2). 1Show
81CTTNSRC8_HUMANSrc substrate cortactin (Amplaxin) (Oncogene EMS1). 7Show
82SRCSRC_HUMANProto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src). 5Show
83STAT5ASTA5A_HUMANSignal transducer and activator of transcription 5A. 1Show
84STAT5BSTA5B_HUMANSignal transducer and activator of transcription 5B. 2Show
85STAP2STAP2_HUMANSignal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinasesubstrate) (BRK substrate). 2Show
86STAT1STAT1_HUMANSignal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84). 1Show
87STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 3Show
88SNCASYUA_HUMANAlpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 componentof amyloid precursor) (NACP). 1Show
89TERTTERT_HUMANTelomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalyticsubunit) (HEST2) (Telomerase-associated protein 2) (TP2). 2Show
90TXKTXK_HUMANTyrosine-protein kinase TXK (EC 2.7.10.2). 1Show
91VIL1VILI_HUMANVillin-1. 3Show
92VCLVINC_HUMANVinculin (Metavinculin). 2Show
93WASF1WASF1_HUMANWiskott-Aldrich syndrome protein family member 1 (WASP family proteinmember 1) (Protein WAVE-1) (Verprolin homology domain-containingprotein 1). 1Show
94ZAP70ZAP70_HUMANTyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associatedprotein) (Syk-related tyrosine kinase). 1Show