Regulatory Network in Protein Phosphorylation
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Kinase: HCK hemopoietic cell kinase

Group: TK      Family: Src      Subfamily: SrcB

Description: hemopoietic cell kinase

Gene Symbol: HCK

Synonyms: JTK9

UniprotKB/SwissProt: HCK_HUMAN (P08631)

Function: May serve as part of a signaling pathway coupling the Fc receptor to the activation of the respiratory burst. May also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.

Subcellular Localization: Isoform p59-HCK: Membrane; Lipid-anchor. Isoform p60-HCK: Membrane; Lipid-anchor. Cytoplasm.

Protein Domain:
PDB:1AD5

The substrate proteins of kinase HCK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1ADAM15ADA15_HUMANADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinasedomain 15) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein)(Metargidin). 1Show
2BCRBCR_HUMANBreakpoint cluster region protein (EC 2.7.11.1) (Renal carcinomaantigen NY-REN-26). 2Show
3CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 2Show
4CSF3RCSF3R_HUMANGranulocyte colony-stimulating factor receptor precursor (G-CSF-R)(CD114 antigen). 2Show
5HCKHCK_HUMANTyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK)(Hemopoietic cell kinase). 5Show
6PLCG1PLCG1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1)(Phospholipase C-gamma-1) (PLC-II) (PLC-148). 3Show
7PLCG2PLCG2_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2)(Phospholipase C-gamma-2) (PLC-IV). 2Show
8RAPGEF1RPGF1_HUMANRap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasingfactor 2) (C3G protein) (CRK SH3-binding GNRP). 2Show
9STAT5BSTA5B_HUMANSignal transducer and activator of transcription 5B. 1Show
10STAT3STAT3_HUMANSignal transducer and activator of transcription 3 (Acute-phaseresponse factor). 2Show
11WASWASP_HUMANWiskott-Aldrich syndrome protein (WASp). 2Show