|Group: TK Family: Syk |
Description: zeta-chain (TCR) associated protein kinase 70kDa
Gene Symbol: ZAP70
Synonyms: SRK, STD, TZK, ZAP-70
UniprotKB/SwissProt: ZAP70_HUMAN (P43403)
Function: Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.
Subcellular Localization: Cytoplasm (By similarity). Note=After antigen stimulation, isoform 1 concentrates at the immunological synapse and isoform 2 remains cytoplasmic (By similarity).