Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinome Table]
Kinase: ZAP70 zeta-chain (TCR) associated protein kinase 70kDa

Group: TK      Family: Syk      

Description: zeta-chain (TCR) associated protein kinase 70kDa

Gene Symbol: ZAP70

Synonyms: SRK, STD, TZK, ZAP-70

UniprotKB/SwissProt: ZAP70_HUMAN (P43403)

Function: Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.

Subcellular Localization: Cytoplasm (By similarity). Note=After antigen stimulation, isoform 1 concentrates at the immunological synapse and isoform 2 remains cytoplasmic (By similarity).

Protein Domain:
PDB:1M61

The substrate proteins of kinase ZAP70

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1DBNLDBNL_HUMANDrebrin-like protein (SH3 domain-containing protein 7) (Drebrin-F)(Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55)(Cervical mucin-associated protein). 4Show
2DUSP3DUS3_HUMANDual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16)(Dual specificity protein phosphatase VHR). 2Show
3GAB2GAB2_HUMANGRB2-associated-binding protein 2 (Growth factor receptor boundprotein 2-associated protein 2) (GRB2-associated binder 2) (pp100). 2Show
4LATLAT_HUMANLinker for activation of T-cells family member 1 (36 kDa phospho-tyrosine adapter protein) (pp36) (p36-38). 5Show
5LCP2LCP2_HUMANLymphocyte cytosolic protein 2 (SH2 domain-containing leukocyteprotein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76). 6Show
6MAPK14MK14_HUMANMitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activatedprotein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressiveanti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP)(MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A). 1Show
7MUC1MUC1_HUMANMucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)]. 1Show
8SH2B3SH2B3_HUMANSH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)(Signal transduction protein Lnk) (Lymphocyte adapter protein). 2Show
9SHC1SHC1_HUMANSHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2domain-containing-transforming protein C1). 5Show
10ZAP70ZAP70_HUMANTyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associatedprotein) (Syk-related tyrosine kinase). 10Show



The substrate proteins of kinase family Syk

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1SH3BP23BP2_HUMANSH3 domain-binding protein 2 (3BP-2). 3Show
2SLC4A1B3AT_HUMANBand 3 anion transport protein (Anion exchange protein 1) (AE 1)(Solute carrier family 4 member 1) (CD233 antigen). 8Show
3BLNKBLNK_HUMANB-cell linker protein (Cytoplasmic adapter protein) (B-cell adaptercontaining a SH2 domain protein) (B-cell adapter containing a Srchomology 2 domain protein) (Src homology 2 domain-containing leukocyteprotein of 65 kDa) (SLP-65). 4Show
4BTKBTK_HUMANTyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK). 1Show
5CBLCBL_HUMANE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55). 3Show
6DUSP3DUS3_HUMANDual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16)(Dual specificity protein phosphatase VHR). 1Show
7PTK2BFAK2_HUMANProtein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2)(FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta)(CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Relatedadhesion focal tyrosine kinase) (RAFTK). 1Show
8FCGR2AFCG2A_HUMANLow affinity immunoglobulin gamma Fc region receptor II-a precursor(Fc-gamma RII-a) (FcRII-a) (IgG Fc receptor II-a) (Fc-gamma-RIIa)(CD32 antigen) (CDw32). 6Show
9FCGR2CFCG2C_HUMANLow affinity immunoglobulin gamma Fc region receptor II-c precursor(Fc-gamma RII-c) (FcRII-c) (IgG Fc receptor II-c) (Fc-gamma-RIIc)(CD32 antigen) (CDw32). 1Show
10HCLS1HCLS1_HUMANHematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75). 4Show
11ITGB3ITB3_HUMANIntegrin beta-3 precursor (Platelet membrane glycoprotein IIIa)(GPIIIa) (CD61 antigen). 2Show
12PRKCAKPCA_HUMANProtein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A). 2Show
13SYKKSYK_HUMANTyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase). 10Show
14LCKLCK_HUMANProto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK)(Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase). 1Show
15LCP2LCP2_HUMANLymphocyte cytosolic protein 2 (SH2 domain-containing leukocyteprotein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76). 2Show
16MAP4K1M4K1_HUMANMitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1)(MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)(Hematopoietic progenitor kinase). 2Show
17PLCG1PLCG1_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1)(Phospholipase C-gamma-1) (PLC-II) (PLC-148). 4Show
18SHC1SHC1_HUMANSHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2domain-containing-transforming protein C1). 4Show
19SNCASYUA_HUMANAlpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 componentof amyloid precursor) (NACP). 5Show
20TUBA4ATBA4A_HUMANTubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1)(Testis-specific alpha-tubulin) (Tubulin H2-alpha). 1Show
21TYROBPTYOBP_HUMANTYRO protein tyrosine kinase-binding protein precursor (DNAX-activation protein 12) (Killer-activating receptor-associatedprotein). 4Show