Regulatory Network in Protein Phosphorylation
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Kinase: ZAP70 zeta-chain (TCR) associated protein kinase 70kDa

Group: TK      Family: Syk      

Description: zeta-chain (TCR) associated protein kinase 70kDa

Gene Symbol: ZAP70

Synonyms: SRK, STD, TZK, ZAP-70

UniprotKB/SwissProt: ZAP70_HUMAN (P43403)

Function: Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.

Subcellular Localization: Cytoplasm (By similarity). Note=After antigen stimulation, isoform 1 concentrates at the immunological synapse and isoform 2 remains cytoplasmic (By similarity).

Protein Domain:
PDB:1M61

The subs