Regulatory Network in Protein Phosphorylation
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Kinase: ITK IL2-inducible T-cell kinase

Group: TK      Family: Tec      

Description: IL2-inducible T-cell kinase

Gene Symbol: ITK

Synonyms: EMT, LYK, MGC126257, MGC126258, PSCTK2

UniprotKB/SwissProt: ITK_HUMAN (Q08881)

Function: Plays a role in T-cell proliferation and differentiation.

Subcellular Localization: Cell membrane (By similarity). Note=Localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T- cells (By similarity).

Protein Domain:
PDB:1SM2

The substrate proteins of kinase ITK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1BMXBMX_HUMANCytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrowtyrosine kinase gene in chromosome X protein) (Epithelial andendothelial tyrosine kinase) (ETK) (NTK38). 2Show
2BTKBTK_HUMANTyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK). 1Show
3CD28CD28_HUMANT-cell-specific surface glycoprotein CD28 precursor (TP44). 7Show
4ITKITK_HUMANTyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase)(Tyrosine-protein kinase Lyk) (Kinase EMT). 1Show
5SIGLEC10SIG10_HUMANSialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec-like protein 2). 2Show
6TECTEC_HUMANTyrosine-protein kinase Tec (EC 2.7.10.2). 1Show



The substrate proteins of kinase family Tec

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1BMXBMX_HUMANCytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrowtyrosine kinase gene in chromosome X protein) (Epithelial andendothelial tyrosine kinase) (ETK) (NTK38). 3Show
2BTKBTK_HUMANTyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK). 1Show
3PTPN18PTN18_HUMANTyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48)(Brain-derived phosphatase). 3Show
4TECTEC_HUMANTyrosine-protein kinase Tec (EC 2.7.10.2). 2Show