Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinome Table]
Kinase: BTK Bruton agammaglobulinemia tyrosine kinase

Group: TK      Family: Tec      

Description: Bruton agammaglobulinemia tyrosine kinase

Gene Symbol: BTK

Synonyms: AGMX1, AT, ATK, BPK, IMD1, MGC126261, MGC126262, PSCTK1, XLA

UniprotKB/SwissProt: BTK_HUMAN (Q06187)

Function: Plays a crucial role in B-cell ontogeny. Transiently phosphorylates GTF2I on tyrosine residues in response to B-cell receptor cross-linking. Required for the formation of functional ARID3A DNA-binding complexes.

Subcellular Localization: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity).

Protein Domain:
PDB:1AWW

The substrate proteins of kinase BTK

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1BMXBMX_HUMANCytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrowtyrosine kinase gene in chromosome X protein) (Epithelial andendothelial tyrosine kinase) (ETK) (NTK38). 4Show
2BTKBTK_HUMANTyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK). 3Show
3CD19CD19_HUMANB-lymphocyte antigen CD19 precursor (Differentiation antigen CD19) (B-lymphocyte surface antigen B4) (Leu-12). 2Show
4DAPP1DAPP1_HUMANDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B-cell adapter molecule of 32 kDa) (Blymphocyte adapter protein Bam32). 1Show
5GTF2IGTF2I_HUMANGeneral transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosinekinase-associated protein 135) (BTK-associated protein 135) (BAP-135)(SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndromechromosomal region 6 protein). 8Show
6ITKITK_HUMANTyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase)(Tyrosine-protein kinase Lyk) (Kinase EMT). 1Show
7PLCG2PLCG2_HUMAN1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2)(Phospholipase C-gamma-2) (PLC-IV). 6Show
8STAT5ASTA5A_HUMANSignal transducer and activator of transcription 5A. 1Show
9TECTEC_HUMANTyrosine-protein kinase Tec (EC 2.7.10.2). 1Show
10WASWASP_HUMANWiskott-Aldrich syndrome protein (WASp). 2Show



The substrate proteins of kinase family Tec

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1BMXBMX_HUMANCytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrowtyrosine kinase gene in chromosome X protein) (Epithelial andendothelial tyrosine kinase) (ETK) (NTK38). 3Show
2BTKBTK_HUMANTyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK). 1Show
3PTPN18PTN18_HUMANTyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48)(Brain-derived phosphatase). 3Show
4TECTEC_HUMANTyrosine-protein kinase Tec (EC 2.7.10.2). 2Show