Regulatory Network in Protein Phosphorylation
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Kinase: TIE2 TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)

Group: TK      Family: Tie      

Description: TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)

Gene Symbol: TEK

Synonyms: CD202B, TIE-2, TIE2, VMCM, VMCM1

UniprotKB/SwissProt: TIE2_HUMAN (Q02763)

Function: This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.

Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein Domain:
PDB:1FVR

The substrate proteins of kinase TIE2

No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase-specific phosphorylation sitesView
1TEKTIE2_HUMANAngiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-proteinkinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK)(p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen). 7Show



The substrate proteins of kinase family Tie

 No.Gene NameUniProtKB IDProtein DescriptionNumber of kinase family-specific phosphorylated sitesView
1TEKTIE2_HUMANAngiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-proteinkinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK)(p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen). 7Show