|Group: TK Family: Tie |
Description: TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)
Gene Symbol: TEK
Synonyms: CD202B, TIE-2, TIE2, VMCM, VMCM1
UniprotKB/SwissProt: TIE2_HUMAN (Q02763)
Function: This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.
Subcellular Localization: Membrane; Single-pass type I membrane protein.